|
|
| | 3-Oxo-cyclopentanecarbonitrile Basic information |
| | 3-Oxo-cyclopentanecarbonitrile Chemical Properties |
| Boiling point | 250-270 °C(Press: 1 Torr) | | density | 1.08±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | InChI | 1S/C6H7NO/c7-4-5-1-2-6(8)3-5/h5H,1-3H2 | | InChIKey | RJDDBRGASHENKL-UHFFFAOYSA-N | | SMILES | N#CC1CCC(=O)C1 |
| WGK Germany | WGK 3 | | HS Code | 2926907090 | | Storage Class | 10 - Combustible liquids |
| | 3-Oxo-cyclopentanecarbonitrile Usage And Synthesis |
| Uses | 3-Cyanocyclopentanone is used for catalytic enantioselective conjugate addition of cyanide to enones. | | Definition | ChEBI: An alicyclic ketone that is cyclopentanone substituted at position 3 by a cyano group. | | Synthesis Reference(s) | The Journal of Organic Chemistry, 38, p. 3455, 1973 DOI: 10.1021/jo00960a002 | | Synthesis | General procedure for the synthesis of 3-oxocyclopentanecarbonitrile from 2-cyclopentenone: a mixed solution of 2-cyclopentenone (10 g, 122 mmol), potassium cyanide (9.5 g, 146 mmol), and triethylamine hydrochloride (25 g, 83 mmol) in methanol (150 mL) was stirred for 4 hours at room temperature. Upon completion of the reaction, the reaction mixture was concentrated; the residue was redissolved in ethyl acetate. The resulting solution was washed sequentially with water and saturated saline, dried over anhydrous sodium sulfate and concentrated. The residue was purified by silica gel column chromatography (petroleum ether: ethyl acetate = 5:1) to give 7.5 g of 3-oxocyclopentanecarbonitrile.1H NMR (400 MHz, CDCl3): δ 3.13-3.51 (m, 1H), 2.56-2.63 (m, 1H), 2.16-2.48 (m, 5H). | | References | [1] Journal of Organic Chemistry, 1997, vol. 62, # 15, p. 5144 - 5155
[2] Chemical and Pharmaceutical Bulletin, 1985, vol. 33, # 5, p. 2164 - 2167
[3] Patent: WO2013/28670, 2013, A1. Location in patent: Page/Page column 119; 120 |
| | 3-Oxo-cyclopentanecarbonitrile Preparation Products And Raw materials |
|