伊曲茶碱杂质
| 中文名称 | 伊曲茶碱杂质 |
|---|---|
| 中文同义词 | 伊曲茶碱杂质14;4-去甲基伊曲茶碱;4-去甲基异氟烷;伊曲茶碱杂质869;伊曲茶碱10;化合物 4-Desmethyl Istradefylline |
| 英文名称 | 4-DesMethyl Istradefylline |
| 英文同义词 | (E)-1,3-diethyl-8-(4-hydroxy-3-methoxystyryl)-7-methyl-1H-purine-2,6(3H,7H)-dione;4-DesMethyl Istradefylline impurity;Istradefylline Impurity 14;Istradefylline 4-O-Desmethyl Impurity;1H-Purine-2,6-dione, 1,3-diethyl-3,7-dihydro-8-[2-(4-hydroxy-3-methoxyphenyl)ethenyl]-7-methyl-, (E)- (9CI);Istradefylline M1 metabolite;Itraphylline impurities869;Itraphylline impurities6 |
| CAS号 | 160434-48-0 |
| 分子式 | C19H22N4O4 |
| 分子量 | 370.4 |
| EINECS号 | |
| 相关类别 | 杂质对照品;Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals |
| Mol文件 | 160434-48-0.mol |
| 结构式 |  |
伊曲茶碱杂质 性质
| 沸点 | 604.8±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.30±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 9.88±0.31(Predicted) |
4-Desmethyl Istradefylline 是 Istradefylline 的代谢物。Istradefylline 是一种有效的，选择性的，可口服的 adenosine A2A receptor 拮抗剂，在帕金森疾病模型试验中，Ki 值为 2.2 nM。
用途
4-Desmethyl Istradefylline is an impurity of Istradefylline (I927000), a selective A(2A) antagonist used in the treatment of Parkinson鈥檚 disease. 4-Desmethyl Istradefylline have also been shown to exh
ibit inhibitory potency towards adenosine A2A receptors and is classified as its an adenosine A2A receptor antagonist.