|
|
| Product Name: | DH 97 | | Synonyms: | DH 97;N-PENTANOYL-2-BENZYLTRYPTAMINE;1-Pentanone,1-[3-(2-aminoethyl)-2-(phenylmethyl)-1H-indol-1-yl]-;N-[2-(2-benzyl-1H-indol-3-yl)ethyl]pentanamide | | CAS: | 343263-95-6 | | MF: | C22H26N2O | | MW: | 334.46 | | EINECS: | | | Product Categories: | Melatonin receptor | | Mol File: | 343263-95-6.mol |  |
| | DH 97 Chemical Properties |
| Boiling point | 488.6±35.0 °C(Predicted) | | density | 1.09±0.1 g/cm3(Predicted) | | storage temp. | Store at RT | | solubility | DMSO: soluble | | form | A crystalline solid | | pka | 9.53±0.10(Predicted) |
| | DH 97 Usage And Synthesis |
| Description | DH 97 is an antagonist of melatonin receptor 2 (MT2; Kis = 252 and 1,100 for human MT2 and MT1 receptors, respectively). | | Uses | DH97 is a potent melatonin receptor 2 (MT2) antagonist with Ki values of 252 nM and 1100 nM for MT2 and MT1, respectively[1]. | | Definition | ChEBI: N-[2-[2-(phenylmethyl)-1H-indol-3-yl]ethyl]pentanamide is a member of indoles. | | Biological Activity | A relatively potent MT 2 melatonin receptor antagonist (pK i value = 8.03), displaying 89- and 229-fold selectivity over MT 1 and GPR50 (melatonin-related orphan receptor) respectively. | | IC 50 | MT2: 252 nM (Ki); MT1: 1100 nM (Ki) | | References | [1] O Nosjean, et al. Comparative pharmacological studies of melatonin receptors: MT1, MT2 and MT3/QR2. Tissue distribution of MT3/QR2. Biochem Pharmacol. 2001 Jun 1;61(11):1369-79. DOI:10.1016/s0006-2952(01)00615-3 |
| | DH 97 Preparation Products And Raw materials |
|