- Equisetin
-
- $3230.00 / 50mg
-
2026-04-13
- CAS:57749-43-6
- Min. Order:
- Purity:
- Supply Ability: 10g
- EQUISETIN
-
- $1.00 / 1g
-
2019-12-26
- CAS:57749-43-6
- Min. Order: 1g
- Purity: ≥98%
- Supply Ability: g/kg/Ton
|
| | EQUISETIN Basic information |
| Product Name: | EQUISETIN | | Synonyms: | EQUISETIN;LS-64262;2,4-Pyrrolidinedione, 5-(hydroxymethyl)-3-[hydroxy[(1S,2R,4aS,6R,8aR)-1,2,4a,5,6,7,8,8a-octahydro-1,6-dimethyl-2-(1E)-1-propen-1-yl-1-naphthalenyl]methylene]-1-methyl-, (3E,5S)-;(3E,5S)-3-[[(1S,2R,4aS,6R,8aR)-1,6-dimethyl-2-[(E)-prop-1-enyl]-4a,5,6,7,8,8a-hexahydro-2H-naphthalen-1-yl]-hydroxymethylidene]-5-(hydroxymethyl)-1-methylpyrrolidine-2,4-dione;Citalopram Impurity 39;(3E,5S)-3-{[(1S,2R,4aS,6R,8aR)-1,6-dimethyl-2-[(1E)-prop-1-en-1-yl]-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(hydroxymethyl)-1-methylpyrrolidine-2,4-dione | | CAS: | 57749-43-6 | | MF: | C22H31NO4 | | MW: | 373.49 | | EINECS: | | | Product Categories: | | | Mol File: | 57749-43-6.mol |  |
| | EQUISETIN Chemical Properties |
| Melting point | 117-118 °C | | Boiling point | 556.0±50.0 °C(Predicted) | | density | 1.180±0.06 g/cm3(Predicted) | | storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere | | solubility | Acetone (Slightly), DMSO (Slightly), Methanol (Slightly) | | pka | 4.50±1.00(Predicted) | | form | Solid | | color | Pale Beige to Light Brown | | Stability: | Hygroscopic |
| HS Code | 29339900 | | Toxicity | mouse,LD50,intraperitoneal,63mg/kg (63mg/kg),Antimicrobial Agents and Chemotherapy. Vol. 5, Pg. 634, 1974. |
| | EQUISETIN Usage And Synthesis |
| Description | Equisetin is a fungal metabolite that has been isolated from Fusarium. It inhibits HIV-1 integrase 3’ end-processing and strand transfer activities. Equisetin inhibits the ATPase activity of rat liver mitochondria and mitoplasts stimulated by 2,4-dinitrophenol (Dnp) in a concentration-dependent manner (IC50 = ~8 nM per mg of protein for both). It also inhibits ADP-stimulated respiration and the mitochondrial transport of ATP, inorganic phosphate, and succinate. Epiequisetin is phytotoxic and inhibits the germination of various seeds and growth of young seedlings. | | Uses | The tetramic acid, equisetin, is produced by a number of species of Fusarium. Interest in equisetin emerged with reports of its inhibitory activity against HIV-1 integrase in vitro that was mechanistically distinct from previously described inhibitors. Equisetin inhibits 3' end-processing and strand transfer, as well as disintegration catalysed by either the full-length enzyme or the truncated integrase core. | | Uses | Equisetin is tetramic acid with antibiotic and cytotoxic activity, and a potent inhibitor of HIV-1 integrase. | | in vivo | Equisetin (20-80 mg/kg, i.g., 6 weeks) inhibits obesity and increased energy expenditure in high-fat diet-induced obese mice through inhibition of the enzymatic activity of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)[5].
Equisetin (10 mg/kg, i.p., 6 h) shows significant anti-infective activity in a mouse model of Staphylococcus aureus ATCC 29213 infection[8].
Equisetin (5-20 mg/kg, p.o., every two days until 12 weeks) prevents atherosclerosis in mice by binding to and inhibiting the activity of STAT3[10].
| Animal Model: | Atherosclerosis model (eight-week-old male ApoE-/- mice were fed with HFD for 12 weeks)[10] | | Dosage: | 5, 20 mg/kg | | Administration: | Oral gavage (p.o.), every two days until 12 weeks | | Result: | Attenuated HFD-induced lipid area in the en face prepared aorta and aortic root.
Attenuated atherosclerotic lesion area (HFD versus HFD+5mg/kg Equisetin: 31.71 versus 16.95; HFD versus HFD+20mg/kg Equisetin: 31.71 versus 10.12).
Increased collagen content in the aortic plaques.
Increased α-SMA-positive areas in the plaques in aortic root.
|
| | IC 50 | STAT3 | | References | [1] A.E. DESJARDINS R. H P. Molecular biology of Fusarium mycotoxins[J]. International journal of food microbiology, 2007, 119 1: Pages 47-50. DOI: 10.1016/j.ijfoodmicro.2007.07.024
[2] BHARGAVI PATHAM. Post-translational import of protein into the endoplasmic reticulum of a trypanosome: an in vitro system for discovery of anti-trypanosomal chemical entities.[J]. Biochemical Journal, 2009, 419 2: 507-517. DOI: 10.1042/bj20081787
[3] SHEO B. SINGH . Equisetin and a novel opposite stereochemical homolog phomasetin, two fungal metabolites as inhibitors of HIV-1 integrase[J]. Tetrahedron Letters, 1998, 39 16: Pages 2243-2246. DOI: 10.1016/s0040-4039(98)00269-x
[4] T KNIG B S A Kapus. Effects of equisetin on rat liver mitochondria: evidence for inhibition of substrate anion carriers of the inner membrane.[J]. Journal of Bioenergetics and Biomembranes, 1993, 25 5: 537-545. DOI: 10.1007/bf01108410
[5] M.H. WHEELER L. S P R D Stipanovic. Phytotoxicity of equisetin and epi-equisetin isolated from Fusarium equiseti and F. pallidoroseum[J]. Mycological research, 1999, 103 8: Pages 967-973. DOI: 10.1017/s0953756298008119 |
| | EQUISETIN Preparation Products And Raw materials |
|