5-(4-Nitrophenyl)-2-furoic acid manufacturers
|
| | 5-(4-Nitrophenyl)-2-furoic acid Basic information |
| | 5-(4-Nitrophenyl)-2-furoic acid Chemical Properties |
| Melting point | 255-257 °C (dec.)(lit.) | | Boiling point | 451.4±35.0 °C(Predicted) | | density | 1.440±0.06 g/cm3(Predicted) | | pka | 2.80±0.10(Predicted) | | InChI | InChI=1S/C11H7NO5/c13-11(14)10-6-5-9(17-10)7-1-3-8(4-2-7)12(15)16/h1-6H,(H,13,14) | | InChIKey | FXZTYDPWMQBTDH-UHFFFAOYSA-N | | SMILES | O1C(C2=CC=C([N+]([O-])=O)C=C2)=CC=C1C(O)=O | | CAS DataBase Reference | 28123-73-1(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | HS Code | 29321900 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 5-(4-Nitrophenyl)-2-furoic acid Usage And Synthesis |
| Uses | 5-(4-Nitrophenyl)-2-furoic acid (5-(p-nitrophenyl)-2-furoic acid) is a 5-aryl-2-furoic acid. It is a dantrolene metabolite and its presence in plasma and urine has been determined by HPLC. It was reported to be the only product formed during the reduction of 5-(4-nitrophenyl)-2-furaldehyde by modified Cannizzaro reaction. | | Synthesis Reference(s) | [1] Mori, M.;Tresoldi, A.; Villa,
S.;Cazzaniga, G.;Bellinzoni,
M.;Meneghetti, F.5-(4-Nitrophenyl)furan-2-carboxylic Acid. Molbank 2022, 2022, M1515. | | General Description | 5-(4-Nitrophenyl)-2-furoic acid (5-(p-nitrophenyl)-2-furoic acid) is a 5-aryl-2-furoic acid. It is a dantrolene metabolite and its presence in plasma and urine has been determined by HPLC. It was reported to be the only product formed during the reduction of 5-(4-nitrophenyl)-2-furaldehyde by modified Cannizzaro reaction. | | Synthesis | To a solution of methyl 5-(4-nitrophenyl)furan-2-carboxylate (2, 50 mg, 0.2 mmol) in a mixture of H2O
(2.6 mL) and MeOH (1.3 mL) was added NaOH (24 mg, 0.6 mmol). The
reaction mixture was stirred at reflux for 3 h and partially concentered
in vacuo to remove the solvent; then, 1 M HCl was added to adjust the
pH to 3–4. The aqueous phase was extracted with EtOAc (3 × 5 mL), the
combined organic phases were dried over anhydrous Na2SO4, filtered, and evaporated under reduced pressure to obtain 5-(4-NITROPHENYL)-2-FUROIC ACID as a yellow solid.[1] |
| | 5-(4-Nitrophenyl)-2-furoic acid Preparation Products And Raw materials |
|