| Company Name: |
BOC Sciences |
| Tel: |
16314854226; +8616314854226 |
| Email: |
inquiry@bocsci.com |
| Company Name: |
BOC Sciences |
| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
|
| | AR 244555 Basic information |
| Product Name: | AR 244555 | | Synonyms: | AR 244555;Methanone, [1'-(3-buten-1-yl)-5-chloro-1,2-dihydrospiro[3H-indole-3,4'-piperidin]-1-yl](2,6-difluorophenyl)- | | CAS: | 858350-62-6 | | MF: | C23H23ClF2N2O | | MW: | 416.89 | | EINECS: | | | Product Categories: | | | Mol File: | 858350-62-6.mol |  |
| | AR 244555 Chemical Properties |
| Boiling point | 546.0±50.0 °C(Predicted) | | density | 1.31±0.1 g/cm3(Predicted) | | pka | 9.53±0.20(Predicted) |
| | AR 244555 Usage And Synthesis |
| Uses | AR244555 is a malate-aspartate shuttle (MAS) inverse agonist with IC50s of 186 nM and 348 nM in human and rat inositol phosphatase (IP) Gq coupling assays respectively. AR244555 has cardioprotective effects[1]. | | References | [1] Tong Zhang, et al. Inhibition of Mas G-protein signaling improves coronary blood flow, reduces myocardial infarct size, and provides long-term cardioprotection. Am J Physiol Heart Circ Physiol. 2012 Jan 1;302(1):H299-311. DOI:10.1152/ajpheart.00723.2011 |
| | AR 244555 Preparation Products And Raw materials |
|