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| | MRGPRX1 agonist 1 Basic information |
| Product Name: | MRGPRX1 agonist 1 | | Synonyms: | MRGPRX1 agonist 1;MRGPRX1 agonist 1,Inhibitor,MRGPRX-1 agonist 1,inhibit;Benzenesulfonamide, N-[2-[(1-amino-6-isoquinolinyl)oxy]-4-methylphenyl]-2-methoxy-;BUN79398;N-(2-((1-Aminoisoquinolin-6-yl)oxy)-4-methylphenyl)-2-methoxybenzenesulfonamide;MRGPRX1 agonist 1, 10 mM in DMSO | | CAS: | 2377379-39-8 | | MF: | C23H21N3O4S | | MW: | 435.5 | | EINECS: | | | Product Categories: | | | Mol File: | 2377379-39-8.mol |  |
| | MRGPRX1 agonist 1 Chemical Properties |
| Boiling point | 642.0±65.0 °C(Predicted) | | density | 1.365±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 130 mg/mL (298.51 mM; Need ultrasonic) | | pka | 8.81±0.10(Predicted) | | form | Solid | | color | White to yellow | | InChI | InChI=1S/C23H21N3O4S/c1-15-7-10-19(26-31(27,28)22-6-4-3-5-20(22)29-2)21(13-15)30-17-8-9-18-16(14-17)11-12-25-23(18)24/h3-14,26H,1-2H3,(H2,24,25) | | InChIKey | BWEJNHRMGZUMNU-UHFFFAOYSA-N | | SMILES | C1(S(NC2=CC=C(C)C=C2OC2C=CC3=C(C=2)C=CN=C3N)(=O)=O)=CC=CC=C1OC |
| | MRGPRX1 agonist 1 Usage And Synthesis |
| Uses | MRGPRX1 agonist 1 is a highly potent agonist of MRGPRX1 (Mas-related G-protein-coupled receptor X1), with an EC50 of 50 nM, and is inactive on MRGPRC11. Analgesic effect[1]. | | Biological Activity | MRGPRX1 agonist 1 is a highly potent agonist of MRGPRX1 (Mas-related G-protein-coupled receptor X1), with an EC50 of 50 nM, and is inactive on MRGPRC11. Analgesic effect[1]. | | References | [1]. Prchalová E, et al. Discovery of Benzamidine- and 1-Aminoisoquinoline-Based Human MAS-Related G-Protein-Coupled Receptor X1 (MRGPRX1) Agonists. J Med Chem. 2019 Sep 26;62(18):8631-8641. |
| | MRGPRX1 agonist 1 Preparation Products And Raw materials |
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