Maresin 2 manufacturers
- Maresin 2
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- $1230.00
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2026-07-17
- CAS:1639809-46-3
- Purity:
- Supply Ability: 10g
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| | Maresin 2 Basic information |
| Product Name: | Maresin 2 | | Synonyms: | Maresin 2;4,7,9,11,16,19-Docosahexaenoic acid, 13,14-dihydroxy-, (4Z,7Z,9E,11E,13R,14S,16Z,19Z)-;13,14-Dihydroxydocosahexaenoic acid | | CAS: | 1639809-46-3 | | MF: | C22H32O4 | | MW: | 360.49 | | EINECS: | | | Product Categories: | | | Mol File: | 1639809-46-3.mol |  |
| | Maresin 2 Chemical Properties |
| Boiling point | 559.4±50.0 °C(Predicted) | | density | 1.048±0.06 g/cm3(Predicted) | | storage temp. | Store at -80°C | | solubility | DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): .05 mg/ml | | form | Liquid | | pka | 4.57±0.10(Predicted) | | color | Colorless to light yellow |
| | Maresin 2 Usage And Synthesis |
| Description | Docosahexaenoic acid (DHA; ) is an ω-3 fatty acid that is abundant in the brain and the retina and is known to be important in early development. Maresin 2 (MaR2) is a 13R,14S-dihydroxy DHA formed by recombinant human macrophage 12-lipoxygenase and soluble epoxide hydrolase co-incubated with DHA. At 1 ng/mouse, MaR2 was shown to reduce neutrophil infiltration by 40% in a mouse model of peritonitis, and at 10 pM, MaR2 can enhance human macrophage phagocytosis of zymosan A by 90%. Analytical and biological comparisons of synthetic MaR2 with endogenously derived MaR2 have confirmed its identity as matching the natural product. | | Uses | Maresin 2 is an anti-inflammatory and pro-resolving mediator from human macrophages. Maresins are a new family of anti-inflammatory and pro-resolving lipid mediators biosynthesized from docosahexaenoic acid (DHA) by macrophages[1]. | | Definition | ChEBI: (13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoic acid is a dihydroxydocosahexaenoic acid that is (4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoic acid in which the two hydroxy substituents are located at the 13R- and 14S-positions. It has a role as a human xenobiotic metabolite, an anti-inflammatory agent and a specialised pro-resolving mediator. It is a dihydroxydocosahexaenoic acid and a secondary allylic alcohol. It is a conjugate acid of a (13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate. | | References | [1] Deng B, et al. Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages. PLoS One. 2014;9(7):e102362. DOI:10.1371/journal.pone.0102362 |
| | Maresin 2 Preparation Products And Raw materials |
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