| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
| Company Name: |
Sigma-Aldrich |
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
|
| | MMP-2 Inhibitor II Basic information |
| Product Name: | MMP-2 Inhibitor II | | Synonyms: | MMP-2 Inhibitor II;N-[4-[4-(oxiran-2-ylmethylsulfonyl)phenoxy]phenyl]methanesulfonamide;MMP-2 Inhibitor II - CAS 869577-51-5 - Calbiochem;N-[4-[4-[(2-oxiranylmethyl)sulfonyl]phenoxy]phenyl]-methanesulfonamide;Methanesulfonamide, N-[4-[4-[(2-oxiranylmethyl)sulfonyl]phenoxy]phenyl]-;MMP-2 Inhibitor II (Matrix Metalloproteinase-2 Inhibitor II) | | CAS: | 869577-51-5 | | MF: | C16H17NO6S2 | | MW: | 383.44 | | EINECS: | | | Product Categories: | | | Mol File: | 869577-51-5.mol |  |
| | MMP-2 Inhibitor II Chemical Properties |
| Boiling point | 591.7±60.0 °C(Predicted) | | density | 1.460±0.06 g/cm3(Predicted) | | storage temp. | -20C | | solubility | ≤200mg/ml in DMSO | | form | White solid | | pka | 8.13±0.10(Predicted) | | color | white | | InChI | 1S/C16H17NO6S2/c1-24(18,19)17-12-2-4-13(5-3-12)23-14-6-8-16(9-7-14)25(20,21)11-15-10-22-15/h2-9,15,17H,10-11H2,1H3 | | InChIKey | ADEXXMLIERNFQB-UHFFFAOYSA-N | | SMILES | [S](=O)(=O)(Nc1ccc(cc1)Oc2ccc(cc2)[S](=O)(=O)CC3OC3)C |
| WGK Germany | WGK 1 | | Storage Class | 11 - Combustible Solids |
| | MMP-2 Inhibitor II Usage And Synthesis |
| Uses | MMP-2 Inhibitor II (compound 2) is a selective MMP-2 inhibitor. The Kinetic parameters for MMP inhibition are 2.4 μM (MMP-2), 45 μM (MMP-1), and 379 μM (MMP-7), respectively[1]. | | General Description | An oxirane analog of SB-3CT, pMS (Cat. No. 444285) that acts as a selective, active site-binding, irreversible inhibitor of MMP-2 (Ki = 2.4 μM). Although less potent, it exhibits enhanced selectivity towards MMP-2 (Ki = 45 and 379 μM for MMP-1 and MMP-7, respectively) than SB-3CT, pMS. | | Biological Activity | mmp-2 inhibitor ii is an irreversible, potent and selective mmp-2 inhibitor with ki value of 2.4 μm [1].matrix metalloproteinases (mmps) are zinc-dependent endopeptidases that play important roles in physiological and pathological conditions. two mmps, gelatinases a and b (mmp-2 and mmp-9, respectively), is highly expressed in human cancer, and a direct relationship between cancer progression and gelatinase expression and activity has been well established [1].mmp-2 inhibitor ii, an oxirane p-sulfonamido analog of sb-3ct, is an irreversible, potent and selective mmp-2 inhibitor. mmp-2 inhibitor ii inhibited mmp-2, mmp-1 and -7 with ki values of 2.4 μm, 45 and 379 μm, respectively, and didn’t inhibit mmp-3, -7, or -9 [1]. in bovine retinal endothelial cells, mmp-2 inhibitor ii reduced glucose-induced increases in the gelatinolytic activity of mmp-2 and mrna levels of mmp-2 and mt1-mmp. mmp-2 inhibitor ii also inhibited glucose-induced alterations in timp-2 and mt1-mmp gene expressions [2]. mmp-2 inhibitor ii had also been used to examine the role of mmp-2 in rheumatoid synovial fibroblast survival, inflammation, and cartilage degradation [3]. | | Biochem/physiol Actions | Secondary TargetMMP-2 (Ki = 45 and 379 μM for MMP-1 and MMP-7, respectively) | | IC 50 | MMP-1: 45 μM (Ki); MMP-2: 2.4 μM (Ki); MMP-7: 379 μM (Ki) | | references | [1]. ikejiri m, bernardo mm, bonfil rd, et al. potent mechanism-based inhibitors for matrix metalloproteinases. j biol chem. 2005 oct 7;280(40):33992-4002.
[2]. kowluru ra, kanwar m. oxidative stress and the development of diabetic retinopathy: contributory role of matrix metalloproteinase-2. free radic biol med. 2009 jun 15;46(12):1677-85.
[3]. xue m, mckelvey k, shen k, et al. endogenous mmp-9 and not mmp-2 promotes rheumatoid synovial fibroblast survival, inflammation and cartilage degradation. rheumatology (oxford). 2014 dec;53(12):2270-9. |
| | MMP-2 Inhibitor II Preparation Products And Raw materials |
|