Robotnikinin manufacturers
- Robotnikinin
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- $1820.00
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2026-07-15
- CAS:1132653-79-2
- Purity:
- Supply Ability: 10g
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| | Robotnikinin Basic information |
| Product Name: | Robotnikinin | | Synonyms: | Robotnikinin;N-(4-chlorobenzyl)-2-((2R,6S,E)-5,12-dioxo-2-phenyl-1-oxa-4-azacyclododec-8-en-6-yl)acetamide;N-[(4-chlorophenyl)methyl]-2-[(2R,6S,8E)-5,12-dioxo-2-phenyl-1-oxa-4-azacyclododec-8-en-6-yl]acetamide;1-Oxa-4-azacyclododec-8-ene-6-acetamide, N-[(4-chlorophenyl)methyl]-5,12-dioxo-2-phenyl-, (2R,6S,8E)-;N-[(4-chlorophenyl)methyl]-5,12-dioxo-2R-phenyl-1-oxa-4-azacyclododec-8E-ene-6S-acetamide | | CAS: | 1132653-79-2 | | MF: | C25H27ClN2O4 | | MW: | 454.95 | | EINECS: | | | Product Categories: | | | Mol File: | 1132653-79-2.mol |  |
| | Robotnikinin Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: Soluble; DMSO: 10 mM; Ethanol: Soluble | | form | A crystalline solid | | color | White |
| | Robotnikinin Usage And Synthesis |
| Description | Robotnikinin is an inhibitor of Shh signaling in a concentration-dependant manner. It acts by displaying significant repression of Shh-induced Gli1/Gli2. | | Uses | Robotnikinin is a small molecule capable of binding to and inhibiting the activity of Sonic Hedgehog (Shh) signaling up stream of Smo[1][2]. | | storage | +4°C | | References | [1] Manuel Hitzenberger, et al. The Binding Mode of the Sonic Hedgehog Inhibitor Robotnikinin, a Combined Docking and QM/MM MD Study. Front Chem DOI:10.3389/fchem.2017.00076
[2] Benjamin Z Stanton, et al. A small molecule that binds Hedgehog and blocks its signaling in human cells. Nat Chem Biol. 2009 Mar;5(3):154-6. DOI:10.1038/nchembio.142
[3] Ronald S Petralia, et al. Sonic hedgehog promotes autophagy in hippocampal neurons. Biol Open. 2013 Apr 8;2(5):499-504. DOI:10.1242/bio.20134275
[4] Ke Cai, et al. Targeting the cross-talk between the hedgehog and NF-κB signaling pathways in multiple myeloma. Leuk Lymphoma. 2019 Mar;60(3):772-781. DOI:10.1080/10428194.2018.1493727 |
| | Robotnikinin Preparation Products And Raw materials |
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