| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
LF3 manufacturers
- LF3
-
- $39.00
-
2026-08-26
- CAS:664969-54-4
- Purity: 99.63%
- Supply Ability: 10g
|
| Product Name: | LF3 | | Synonyms: | LF3;4-[(2E)-3-phenylprop-2-en-1-yl]-N-(4-sulfamoylphenyl)piperazine-1-carbothioamide;LF3 NEW;LF3;LF-3;LF 3;1-Piperazinecarbothioamide, N-[4-(aminosulfonyl)phenyl]-4-(3-phenyl-2-propen-1-yl)-;LF3 >=98% (HPLC);4-(3-Phenylallyl)-N-(4-sulfamoylphenyl)piperazine-1-carbothioamide;β-catenin,LF-3,Beta catenin,LF3,inhibit,Inhibitor,LF 3 | | CAS: | 664969-54-4 | | MF: | C20H24N4O2S2 | | MW: | 416.56 | | EINECS: | | | Product Categories: | | | Mol File: | 664969-54-4.mol |  |
| Boiling point | 609.6±65.0 °C(Predicted) | | density | 1.341±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 20mg/mL | | form | A solid | | pka | 10.00±0.12(Predicted) | | color | White to off-white | | InChI | 1S/C20H24N4O2S2/c21-28(25,26)19-10-8-18(9-11-19)22-20(27)24-15-13-23(14-16-24)12-4-7-17-5-2-1-3-6-17/h1-11H,12-16H2,(H,22,27)(H2,21,25,26)/b7-4+ | | InChIKey | ZUQIFHLBPBLRRM-QPJJXVBHSA-N | | SMILES | S=C(NC1=CC=C(S(N)(=O)=O)C=C1)N2CCN(C/C=C/C3=CC=CC=C3)CC2 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2 |
| Uses | N-[4-(Aminosulfonyl)phenyl]-4-(3-phenyl-2-propenyl)-1-piperazinecarbothioamide is a a 4-thioureido-benzenesulfonamide derivative and a Wnt/β-catenin signaling inhibitor. Wnt/β-catenin signaling is involved with embryogenesis and tissue homeostasis. | | Biological Activity | LF3 is a potent inhibitor of Wnt/β-catenin signaling th at suppresses cancer cells motility, cell-cycle progression, and the overexpression of Wnt target genes. LF3 is a potent and specific antagonist of the interaction between β-catenin and the transcription factor TCF4. LF3 blocks self-renewal of cancer stem cells. | | in vivo | LF3 reduces tumor growth and induces differentiation in a mouse xenograft model of colon cancer. Tumor growth is significantly reduced when mice with GFPhigh cells are treated with LF3 at 50 mg/kg. LF3 treatment does not disturb the normal histology of the gut of mice[1]. |
| | LF3 Preparation Products And Raw materials |
|