化合物UK371804
| 中文名称 | 化合物UK371804 |
|---|---|
| 中文同义词 | 化合物UK371804;化合物UK371804,10 MM DMSO 溶液;2-((4-氯-1-胍基异喹啉)-7-磺酰胺基)-2-甲基丙酸;UK-371804 (UK371804;UK 371804);U879981,UK-371804?,256477-09-5 |
| 英文名称 | UK-371804 |
| 英文同义词 | UK-371804;Urokinase inhibitor 1;Urokinase inhitibor 1;UK-371804 (Urokinase inhitibor 1);Alanine, N-[[1-[(aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methyl-;N-[[1-[(Aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methylalanine;UK 371804,UK-371804,Inhibitor,PAI-1,inhibit,Plasminogen activator inhibitor-1;2-(1-carbamimidamido-4-chloroisoquinoline-7-sulfonamido)-2-methylpropanoic acid |
| CAS号 | 256477-09-5 |
| 分子式 | C14H16ClN5O4S |
| 分子量 | 385.83 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 256477-09-5.mol |
| 结构式 |  |
化合物UK371804 性质
| 沸点 | 634.808±65.00 °C(Press: 760.00 Torr)(predicted) |
|---|---|
| 密度 | 1.632±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO:5.0(最大浓度 mg/mL);2.59(最大浓度 mM) |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 3.252±0.10(predicted) |
| 颜色 | 白色至米白色 |
| CAS 数据库 | 256477-09-5 |
UK-371804是尿嘧啶型纤溶酶原激活物 (uPA) 的抑制剂，Ki值为10 nM。
Ki: 10 nM (uPA)
UK-371804 is able to inhibit exogenous uPA in human chronic wound fluid (IC 50 =0.89 μM). UK-371804 has its excellent enzyme potency (K i =10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).
In a porcine acute excisional wound model, following topical delivery, UK-371804 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. Concentrations of UK-371804 in the dermis are 41.8 μM.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/09/15 | HY-101214 | 化合物UK371804 UK-371804 | 256477-09-5 | 1 mg | 480元 |
| 2026/09/15 | HY-101214 | 化合物UK371804 UK-371804 | 256477-09-5 | 5mg | 1200元 |