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| | NH-(PEG3-t-butyl ester)2 Basic information |
| Product Name: | NH-(PEG3-t-butyl ester)2 | | Synonyms: | NH-(PEG3-t-butyl ester)2;NH-bis(PEG3-t-butyl ester);HN-(PEG3-CH2CH2COOtBu)2;4,7,10,16,19,22-Hexaoxa-13-azapentacosanedioic acid, 1,25-bis(1,1-dimethylethyl) ester;HN-(PEG3-CH2CH2COOtBu)2/4,7,10,16,19,22-Hexaoxa-13-azapentacosanedioic acid, 1,25-bis(1,1-dimethylethyl) ester;13-amino-bis(4,7,10-trioxadodecanoic acid tert-butyl ester);Di-tert-butyl 4,7,10,16,19,22-hexaoxa-13-azapentacosanedioate;NH-(PEG3-CH2CH2COOtBu)2 | | CAS: | 1814901-03-5 | | MF: | C26H51NO10 | | MW: | 537.68 | | EINECS: | | | Product Categories: | | | Mol File: | 1814901-03-5.mol |  |
| | NH-(PEG3-t-butyl ester)2 Chemical Properties |
| Boiling point | 564.7±45.0 °C(Predicted) | | density | 1.050±0.06 g/cm3(Predicted) | | storage temp. | Storage temp. 2-8°C | | solubility | Soluble in Water, DMSO, DCM, DMF | | pka | 8.39±0.19(Predicted) | | form | Liquid | | color | Colorless to light yellow |
| | NH-(PEG3-t-butyl ester)2 Usage And Synthesis |
| Description | NH-bis(PEG3-t-butyl ester) is a PEG linker containing an amino group and 3 PEG units. The amino groups is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | | Uses | NH-bis(PEG3-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | NH-(PEG3-t-butyl ester)2 Preparation Products And Raw materials |
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