Benzenesulfonamide,4-[(3-chloro-1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]-N-2-pyridinyl-

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Benzenesulfonamide,4-[(3-chloro-1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]-N-2-pyridinyl- manufacturers

  • BC-23
  • BC-23 pictures
  • $81.00
  • 2026-05-11
  • CAS:6298-15-3
  • Purity: 99.99%
  • Supply Ability: 10g
Benzenesulfonamide,4-[(3-chloro-1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]-N-2-pyridinyl- Basic information
Product Name:Benzenesulfonamide,4-[(3-chloro-1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]-N-2-pyridinyl-
Synonyms:Benzenesulfonamide,4-[(3-chloro-1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]-N-2-pyridinyl-;BC-23 (BC23;NSC 45382);BC-23;4-((3-Chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)amino)-N-(pyridin-2-yl)benzenesulfonamide;4-[(3-Chloro-1,4-dioxo-1,4-dihydro-2-naphthalenyl)amino]-N-(2-pyridinyl)benzenesulfonamide
CAS:6298-15-3
MF:C21H14ClN3O4S
MW:439.87
EINECS:
Product Categories:
Mol File:6298-15-3.mol
Benzenesulfonamide,4-[(3-chloro-1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]-N-2-pyridinyl- Structure
Benzenesulfonamide,4-[(3-chloro-1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]-N-2-pyridinyl- Chemical Properties
Melting point 262 °C (decomp)(Solv: water (7732-18-5); 1,4-dioxane (123-91-1))
Boiling point 615.9±65.0 °C(Predicted)
density 1.56±0.1 g/cm3(Predicted)
storage temp. +2C to +8C
solubility DMSO: 25mg/mL
form Dark red solid
pka8.47±0.10(Predicted)
color Orange to red
InChI1S/C21H14ClN3O4S/c22-18-19(21(27)16-6-2-1-5-15(16)20(18)26)24-13-8-10-14(11-9-13)30(28,29)25-17-7-3-4-12-23-17/h1-12,24H,(H,23,25)
InChIKeyQRPKNPKHGNUFGK-UHFFFAOYSA-N
Safety Information
WGK Germany WGK 2
Storage Class11 - Combustible Solids
MSDS Information
Benzenesulfonamide,4-[(3-chloro-1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]-N-2-pyridinyl- Usage And Synthesis
UsesBC-23 (NSC 45382) is a proteasome inhibitor. BC-23 exhibits good inhibition of CT-L activity of the proteasome and is selective for malignant over normal cells[1][2].
References[1] Lawrence HR, et, al. Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors. Bioorg Med Chem. 2010 Aug 1;18(15):5576-92. DOI:10.1016/j.bmc.2010.06.038
[2] Zhang Q, et, al. Enhancement of Radiation Sensitivity in Lung Cancer Cells by a Novel Small Molecule Inhibitor That Targets the β-Catenin/Tcf4 Interaction. PLoS One. 2016 Mar 25;11(3):e0152407. DOI:10.1371/journal.pone.0152407
Benzenesulfonamide,4-[(3-chloro-1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]-N-2-pyridinyl- Preparation Products And Raw materials
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