GSK321

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Company Name: BOC Sciences  
Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885 18964387627
Email: info@efebio.com
Company Name: TargetMol Chemicals Inc.  
Tel: +1-781-999-5354; +1-00000000000
Email: marketing@targetmol.com
Company Name: Suzhou Chenrui Biotechnology Co. LTD  
Tel: 17625585511
Email: 1580084073@qq.com
Company Name: Hubei Kele Fine Chemical Co., Ltd  
Tel: 027-59101668 19945030958
Email: 2223443625@qq.com

GSK321 manufacturers

  • GSK321
  • GSK321 pictures
  • $149.00
  • 2026-08-01
  • CAS:1816331-63-1
  • Purity: 99.73%
  • Supply Ability: 10g
GSK321 Basic information
Product Name:GSK321
Synonyms:GSK-321 (GSK321;GSK321;1H-Pyrazolo[4,3-c]pyridine-3-carboxamide, 1-[(4-fluorophenyl)methyl]-4,5,6,7-tetrahydro-N-[3-[(1S)-1-hydroxyethyl]phenyl]-7-methyl-5-(1H-pyrrol-2-ylcarbonyl)-, (7R)-
CAS:1816331-63-1
MF:C28H28FN5O3
MW:501.55
EINECS:
Product Categories:
Mol File:1816331-63-1.mol
GSK321 Structure
GSK321 Chemical Properties
Melting point >120°C (dec.)
Boiling point 704.2±60.0 °C(Predicted)
density 1.35±0.1 g/cm3(Predicted)
storage temp. -20°C Freezer, Under inert atmosphere
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka12.26±0.70(Predicted)
color White to Pale Yellow
Safety Information
MSDS Information
GSK321 Usage And Synthesis
UsesGSK 321 is a potent and selective IDH1 (isocitrate dehydrogenase 1) mutant inhibitor for the treatment of acute myeloid leukemia.
in vivo

GSK321 (150 mg/kg; i.p.; daily, for 15 d; male CD-1 mice with IDH1 mutant AML xenograft) reduces leukemic blasts in vivo[1].

Animal Model:Male CD-1 mice with IDH1 mutant AML xenograft[1]
Dosage:150 mg/kg
Administration:Intraperitoneal injection; daily, for 15 days
Result:Decreased in 2HG in IDH1-mutant AML cells. Decreased in the percentage of blast cells (SSClowCD45low/+) and a relative increase in mature lymphoid and granulocytic/monocytic cells.
GSK321 Preparation Products And Raw materials
Tag:GSK321(1816331-63-1) Related Product Information
1H-Pyrazolo[4,3-c]pyridine-3-carboxamide, 1-[(4-fluorophenyl)methyl]-4,5,6,7-tetrahydro-N-[3-[(1R)-1-hydroxyethyl]phenyl]-7-methyl-5-(1H-pyrrol-2-ylcarbonyl)-, (7S)- GSK321 GSK990 GSK864 1H-Pyrazolo[4,3-c]pyridine-3-carboxamide, 1-[(4-fluorophenyl)methyl]-4,5,6,7-tetrahydro-N-[3-[(1R)-1-hydroxyethyl]phenyl]-7-methyl-5-(1H-pyrrol-2-ylcarbonyl)-, (7R)- 1H-Pyrazolo[4,3-c]pyridine-3-carboxamide, 1-[(4-fluorophenyl)methyl]-4,5,6,7-tetrahydro-N-[3-[(1S)-1-hydroxyethyl]phenyl]-7-methyl-5-(1H-pyrrol-2-ylcarbonyl)-, (7S)-