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| | Ald-CH2-PEG4-CH2CO2tBu Basic information |
| Product Name: | Ald-CH2-PEG4-CH2CO2tBu | | Synonyms: | Ald-CH2-PEG4-CH2CO2tBu;Ald-CH2-PEG3-CH2-Boc;3,6,9,12-Tetraoxatetradecanoic acid, 14-oxo-, 1,1-dimethylethyl ester;OHCCH2O-PEG3-CH2COOtBu | | CAS: | 2100306-54-3 | | MF: | C14H26O7 | | MW: | 306.35 | | EINECS: | | | Product Categories: | | | Mol File: | 2100306-54-3.mol |  |
| | Ald-CH2-PEG4-CH2CO2tBu Chemical Properties |
| Boiling point | 387.8±32.0 °C(Predicted) | | density | 1.071±0.06 g/cm3(Predicted) | | solubility | Soluble in Water, DMSO, DCM, DMF |
| | Ald-CH2-PEG4-CH2CO2tBu Usage And Synthesis |
| Description | Ald-CH2-PEG4-CH2CO2tBu is a PEG linker with aldehyde and t-butyl moieties. Aldehyde is reactive to hydrazide and aminooxy groups which are commonly used in biomolecular probes for labeling and crosslinking carbonyls (oxidized carbohydrates). The t-butyl group can be removed under acidic conditions. The hydrophilic PEG linker increases the water solubility of the compound. | | Uses | Ald-CH2-PEG3-CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of SGK3 kinase PROTAC degrader[1]. | | IC 50 | PEGs; Alkyl/ether | | References | [1] Tovell H, et al. Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader. ACS Chem Biol. 2019 Sep 20;14(9):2024-2034. DOI:10.1021/acschembio.9b00505 |
| | Ald-CH2-PEG4-CH2CO2tBu Preparation Products And Raw materials |
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