RZCPXIZGLPAGEV-SUHLLOIRSA-N manufacturers
- (±)5-iPF2α-VI
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- $917.00
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2026-04-20
- CAS:179094-11-2
- Purity:
- Supply Ability: 10g
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| | RZCPXIZGLPAGEV-SUHLLOIRSA-N Basic information |
| | RZCPXIZGLPAGEV-SUHLLOIRSA-N Chemical Properties |
| Boiling point | 525.4±50.0 °C(Predicted) | | density | 1.153±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): .5 mg/ml | | pka | 4.68±0.10(Predicted) |
| | RZCPXIZGLPAGEV-SUHLLOIRSA-N Usage And Synthesis |
| Description | Isoprostanes are prostaglandin (PG)-like products of free-radical induced lipid peroxidation. Although the isoprostanes derived from arachidonic acid are the best characterized, many other polyunsaturated fatty acids can form isoprostanes. (±)5-iPF2α-VI is one of dozens of possible stereo- and regioisomeric isoprostanes which can be formed from arachidonic acid. To date, the most extensively studied of these is 8-isoprostane (8-epi-PGF2α, iPF2α-III). However, 8-isoprostane is a minor isoprostane constituent when compared to some of the other isomers which form in natural conditions of oxidative stress. (±)5-iPF2α-VI is an isoprostane from the unique Type VI class of isoprostanes. This class has been shown to be one of the major isoprostane products, in contrast to 8-isoprostane. In addition to being produced in greater abundance than 8-isoprostane, Type VI isoprostanes form internal lactones, which facilitates their extraction and purification from biological samples. | | Uses | (±)5-iPF2α-VI (5-iso Prostaglandin F2α-VI) is the racemate of 5-iPF2α-VI. 5-iPF2α-VI is a regioisomeric isoprostane formed from arachidonic acid (AA) and is a biomarker of oxidative stress[1]. | | References | [1] Morita Y, et al. Simultaneous analyses of urinary eicosanoids and related mediators identified tetranor-prostaglandin E metabolite as a novel biomarker of diabetic nephropathy. J Lipid Res. 2021;62:100120. DOI:10.1016/j.jlr.2021.100120 |
| | RZCPXIZGLPAGEV-SUHLLOIRSA-N Preparation Products And Raw materials |
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