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| | 8,12-iso-iPF2α-VI-1,5-lactone Basic information |
| | 8,12-iso-iPF2α-VI-1,5-lactone Chemical Properties |
| solubility | DMF: 100 mg/ml
DMSO: 100 mg/ml
Ethanol: 100 mg/mlPBS (pH 7.2): 1 mg/ml |
| | 8,12-iso-iPF2α-VI-1,5-lactone Usage And Synthesis |
| Description | F2 isoprostanes (F2-iPs) are thought to arise from the free radical-mediated peroxidation of phospholipid-bound arachidonic acid.1 They are cleaved, presumably by an unidentified phospholipase A2, and are found in the circulation and the urine. 8,12-iso-iPF2α-VI-1,5-lactone is a racemic mixture of the lactone forms of the free acid, 8,12-iso- iPF2α-VI. Previously called IPF2α -I,2 the free acid form, iPF2α-VI, is the most abundant F2-iP regioisomer measured in the urine of rats treated with CCl4 to induce lipid peroxidation.3 iPF2α-VI is the only regioisomer that undergoes lactonization, and this occurs slowly in vivo or can be driven chemically.4 The less polar lactone is readily separated from the free acid forms of iPF2α.4 While the level of iPF2α-VI in plasma, urine and organs is used as a biomarker for oxidative stress,5,6 some F2-iPs also evoke significant biological effects.7 It is not known if 8,12-iso-iPF2α-VI-1,5-lactone has important physiological effects.WARNING This product is not for human or veterinary use. | | References | [1] J A LAWSON. Identification of two major F2 isoprostanes, 8,12-iso- and 5-epi-8, 12-iso-isoprostane F2alpha-VI, in human urine.[J]. The Journal of Biological Chemistry, 1998, 273 45: 29295-29301. DOI: 10.1074/jbc.273.45.29295
[2] J D MORROW. A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1990, 87 23: 9383-9387. DOI: 10.1073/pnas.87.23.9383
[3] RUSSELL J. WAUGH . Identification and Relative Quantitation of F2-Isoprostane Regioisomers Formed in vivo in the Rat[J]. Free Radical Biology and Medicine, 1997, 23 6: Pages 943-954. DOI: 10.1016/s0891-5849(97)00133-0
[4] MUSTAFA ADIYAMAN . Total Synthesis of 17,17,18,18-d4-iPF2α-VI and Quantification of iPF2α-VI in Human Urine by Gas Chromatography/Mass Spectrometry[J]. Analytical biochemistry, 1998, 262 1: Pages 45-56. DOI: 10.1006/abio.1998.2767
[5] D PRATICÒ. IPF2alpha-I: an index of lipid peroxidation in humans.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1998, 95 7: 3449-3454. DOI: 10.1073/pnas.95.7.3449
[6] MIRANDA VAN ECK. Increased oxidative stress in scavenger receptor BI knockout mice with dysfunctional HDL.[J]. Arteriosclerosis, Thrombosis, and Vascular Biology, 2007, 27 11: 2413-2419. DOI: 10.1161/atvbaha.107.145474
[7] CONCETTA GARDI. F2-isoprostane receptors on hepatic stellate cells[J]. Laboratory Investigation, 2007, 88 2: 124-131. DOI: 10.1038/labinvest.3700712 |
| | 8,12-iso-iPF2α-VI-1,5-lactone Preparation Products And Raw materials |
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