| Company Name: |
Energy Chemical |
| Tel: |
400-0056266 |
| Email: |
marketing1@energy-chemical.com |
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| Product Name: | APNA | | Synonyms: | APNA;ARACHIDONOYL P-NITROANILINE;N-(4-NITROPHENYL)-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE;5,8,11,14-Eicosatetraenamide, N-(4-nitrophenyl)-, (5Z,8Z,11Z,14Z)- | | CAS: | 119520-58-0 | | MF: | C26H36N2O3 | | MW: | 424.58 | | EINECS: | | | Product Categories: | | | Mol File: | 119520-58-0.mol |  |
| solubility | DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS (pH 7.2) (1:4): 1 mg/ml; Ethanol: 50 mg/ml |
| Description | Arachidonoyl p-nitroaniline (ApNA) is one of several nitroaniline fatty acid amides which can be used to measure fatty acid amide hydrolase (FAAH) activity. FAAH is a relatively unselective enzyme in that it accepts a variety of amide head groups other than the ethanolamine of its nominal endogenous substrate anandamide (AEA; ). It also will hydrolyze fatty acid amides with fewer carbons and fewer double bonds than arachidonate. (See also Decanoyl p-Nitroaniline - Catalog No. 90349). Exposure of ApNA to FAAH activity results in the release of the yellow colorimetric dye p-nitroaniline (ε = 13,500 at 382 nm). This offers the potential for fast and convenient measurements of FAAH activity using a 96-well plate spectrophotometer. | | Uses | Arachidonoyl p-Nitroaniline is a nitroaniline probe for FAAH activity. | | References | [1] MATTHEW P. PATRICELLI Benjamin F C. Characterization and Manipulation of the Acyl Chain Selectivity of Fatty Acid Amide Hydrolase[J]. Biochemistry Biochemistry, 2001, 40 20: 6107-6115. DOI: 10.1021/bi002578r |
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