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| | ANTI-INFLAMMATORY PEPTIDE 1 Basic information |
| Product Name: | ANTI-INFLAMMATORY PEPTIDE 1 | | Synonyms: | H-MET-GLN-MET-LYS-LYS-VAL-LEU-ASP-SER-OH;ANTI-INFLAMMATORY PEPTIDE 1;ANTIFLAMMIN-I;ANTIFLAMMIN P I;AF-1【peptide】;L-Met-L-Gln-L-Met-L-Lys-L-Lys-L-Val-L-Leu-L-Asp-L-Ser-OH;antiflamminp1;MQMKKVLDS | | CAS: | 118850-71-8 | | MF: | C45H82N12O14S2 | | MW: | 1079.34 | | EINECS: | | | Product Categories: | Immunology;peptide | | Mol File: | 118850-71-8.mol |  |
| | ANTI-INFLAMMATORY PEPTIDE 1 Chemical Properties |
| Boiling point | 1490.7±65.0 °C(Predicted) | | density | 1.270±0.06 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | ≥107.9 mg/mL in DMSO; insoluble in EtOH; ≥21.13 mg/mL in H2O | | pka | 2.85±0.10(Predicted) | | form | Lyophilized powder | | Sequence | H-Met-Gln-Met-Lys-Lys-Val-Leu-Asp-Ser-OH |
| | ANTI-INFLAMMATORY PEPTIDE 1 Usage And Synthesis |
| Uses | Antiflammin-1 is an anti-inflammatory peptide 1 (MQMKKVLDS). Antiflammin-1 is a derivative of uteroglobin. Antiflammin-1 has anti-inflammatory and antifibrotic actions in bleomycin (HY-108345)-induced lung injury[1][2][3]. | | in vivo | Antiflammin-1 (2-10 mg/kg, ip, daily, for 6 days) decreases the levels of TNF-α and IL-1β in bleomycin-treated mice. Antiflammin-1 has anti-inflammatory and antifibrotic actions in bleomycin-induced lung injury[1]. | | IC 50 | IL-1β | | References | [1] Liu W, et al. Antiflammin-1 attenuates bleomycin-induced pulmonary fibrosis in mice. Respir Res. 2013 Oct 8;14(1):101. DOI:10.1186/1465-9921-14-101
[2] Camussi G, et al. Antiinflammatory peptides (antiflammins) inhibit synthesis of platelet-activating factor, neutrophil aggregation and chemotaxis, and intradermal inflammatory reactions. J Exp Med. 1990 Mar 1;171(3):913-27. DOI:10.1084/jem.171.3.913
[3] Martínez Leo EE, et al. Biopeptides with antioxidant and anti-inflammatory potential in the prevention and treatment of diabesity disease. Biomed Pharmacother. 2016 Oct;83:816-826. DOI:10.1016/j.biopha.2016.07.051 |
| | ANTI-INFLAMMATORY PEPTIDE 1 Preparation Products And Raw materials |
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