CTAP

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CTAP Suppliers list
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel: 18930552037
Email: 3bsc@sina.com
Company Name: GL Biochem (Shanghai) Ltd  
Tel: 21-61263452 13641803416
Email: ymbetter@glbiochem.com
Company Name: Shanghai Hanhong Scientific Co.,Ltd.  
Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Company Name: Chemsky (shanghai) International Co.,Ltd  
Tel: 021-50135380
Email: shchemsky@sina.com
Company Name: Shanghai Aladdin Bio-Chem Technology Co.,LTD  
Tel: 400-6206333 13167063860
Email: anhua.mao@aladdin-e.com

CTAP manufacturers

  • CTAP
  • CTAP pictures
  • $1.00
  • 2020-03-06
  • CAS:103429-32-9
  • Min. Order: 1g
  • Purity: ≥98%
CTAP Basic information
Product Name:CTAP
Synonyms:H-D-PHE-CYS-TYR-D-TRP-ARG-THR-PEN-THR-NH2;D-PHE-CYS-TYR-D-TRP-ARG-THR-PEN-THR-NH2;CTAP;CYS2, TYR3, ARG5, PEN7-AMIDE;H-D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2(Cys2-Pen7);CTAP, ≥95%;7)-disulfide;M.W. 1104.30 C51H69N13O11S2
CAS:103429-32-9
MF:C51H69N13O11S2
MW:1104.3
EINECS:
Product Categories:Neuropeptides;Opioid Peptides;Other Opioid Peptides;Other Opioid PeptidesPeptides for Cell Biology;Opioid receptor and opioid-like receptor;Peptide
Mol File:103429-32-9.mol
CTAP Structure
CTAP Chemical Properties
storage temp. -20°C
form Solid
color off-white
Water Solubility Soluble to 1 mg/ml in water
Sequence{d-Phe}-Cys-Tyr-{d-Trp}-Arg-Thr-{Pen}-Thr-NH2 (Disulfide bridge:Cys2-Pen7)
InChIKeyOFMQLVRLOGHAJI-FGHAYEPSSA-N
Safety Information
WGK Germany 3
Storage Class11 - Combustible Solids
MSDS Information
ProviderLanguage
SigmaAldrich English
CTAP Usage And Synthesis
UsesCTAP acts as a selective μ-opioid receptor antagonist with a multitude of applications including the regulation of aggressive behavior in mammals. Activation of μ-opioid receptors in the central nucleus of the amygdala, is responsible for mechanisms related to the control of sodium appetite and regulation of sodium intake.
UsesCTAP has been used as a μ-opioid receptor (MOR) antagonist:
  • to study the anti-hyperalgesic effect of dipeptidyl peptidase 4 (DPP4) inhibitor isoleucine-proline-isoleucine (IPI) and vildagliptin in carrageenan-induced inflammation
  • to study the role of MOR in glutamate and gamma-aminobutyric acid (GABA) efflux during predator stress in rats
  • to determine the endogenous opioid peptide involved in blocking pain induced by activated gastrin-releasing peptide (Grp+) neurons

Biochem/physiol ActionsCTAP is a peptide antagonist produced from somatostatin analogs.
in vivo

CTAP (0-1 mg/kg, IP, single) blocks morphine’s antinociceptive effect[1].
CTAP (10 mg/kg; IP, single) has no effect on L-DOPA-induced limb, axial, orolingual, or locomotor abnormal involuntary movements[1].
CTAP is stable in the blood and serum of rats (T1/2 > 500 min), showing that the structure of this peptide offers enzymatic resistance[2].
CTAP is extensively protein-bound to albumin in the perfusion medium (68.2%) and to proteins in rat serum (84.2%)[2].

Animal Model:Male Sprague-Dawley rats[1]
Dosage:0, 0.1, 0.5, 1 mg/kg
Administration:IP, single
Result:Completely blocked morphine’s antinociceptive effect at 0.5 or 1 mg/kg.
IC 50μ Opioid Receptor/MOR: 3.5 nM (IC50); δ Opioid Receptor/DOR: 4500 nM (IC50)
storageStore at -20°C
CTAP Preparation Products And Raw materials
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