6,9alpha-Methylene-9beta-methyl-11alpha,15s-dihydroxy-prosta-5z,13e-dien-1-oic acid, calcium salt

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6,9alpha-Methylene-9beta-methyl-11alpha,15s-dihydroxy-prosta-5z,13e-dien-1-oic acid, calcium salt manufacturers

6,9alpha-Methylene-9beta-methyl-11alpha,15s-dihydroxy-prosta-5z,13e-dien-1-oic acid, calcium salt Basic information

Product Name:	6,9alpha-Methylene-9beta-methyl-11alpha,15s-dihydroxy-prosta-5z,13e-dien-1-oic acid, calcium salt
Synonyms:	CIPROSTENE CALCIUM;CIPROSTENE CALCIUM SALT;U-61431F;5-(hexahydro-5-hydroxy-6-(3-hydroxy-1-octenyl)-3a-methyl-2(1h)-pentanoicaci;9-beta-methylcarbacyclin;pentalenylidene)-,calciumsalt(2:1),(3as-(2z,3a-alpha,5-beta,6-alpha(1e,3r*;WKRNCYQUQFBOCZ-FCIOBEBZSA-M;6,9alpha-Methylene-9beta-methyl-11alpha,15s-dihydroxy-prosta-5z,13e-dien-1-oic acid, calcium salt
CAS:	81703-55-1
MF:	C22H38CaO4
MW:	406.62
EINECS:
Product Categories:
Mol File:	81703-55-1.mol

6,9alpha-Methylene-9beta-methyl-11alpha,15s-dihydroxy-prosta-5z,13e-dien-1-oic acid, calcium salt Chemical Properties

storage temp.	Store at -20°C
solubility	DMF: > 25 mg/ml; DMSO: > 16.8 mg/ml; ethanol: > 34 mg/ml; PBS pH 7.2: > 0.29 μg/ml
form	A crystalline solid

Safety Information

MSDS Information

6,9alpha-Methylene-9beta-methyl-11alpha,15s-dihydroxy-prosta-5z,13e-dien-1-oic acid, calcium salt Usage And Synthesis

Description	Ciprostene is the 9β-methyl analog of carbaprostacyclin and a stable analog of PGI₂. Ciprostene exhibits biological activity similar to PGI₂, but is 30-fold less potent. In patas monkeys, ciprostene induces hypotension and causes tachycardia when administered at a dose of 0.16 μg/kg/min. In addition, ciprostene inhibits ADP-induced platelet aggregation ex vivo and in vitro with ID₅₀ values of 9.1 μg/kg/min and 60 ng/ml, respectively.
Uses	Platelet aggregation inhibitor.
References	[1] G. ALLAN. The cardiovascular and platelet actions of 9β-methyl carbacyclin (ciprostene), a chemically stable analogue of prostacyclin, in the dog and monkey[J]. British Journal of Pharmacology, 1985, 85 2: 547-555. DOI: 10.1111/j.1476-5381.1985.tb08892.x [2] PAUL A. ARISTOFF Allen W H Paul D Johnson. Synthesis of 9-substituted carbacyclin analogs[J]. The Journal of Organic Chemistry, 1983, 48 26: 5341-5348. DOI: 10.1021/jo00174a035

6,9alpha-Methylene-9beta-methyl-11alpha,15s-dihydroxy-prosta-5z,13e-dien-1-oic acid, calcium salt Preparation Products And Raw materials

Tag:6,9alpha-Methylene-9beta-methyl-11alpha,15s-dihydroxy-prosta-5z,13e-dien-1-oic acid, calcium salt(81703-55-1) Related Product Information

Ciprostene 6,9alpha-Methylene-9beta-methyl-11alpha,15s-dihydroxy-prosta-5z,13e-dien-1-oic acid, calcium salt 8-iso-15(R)-Prostaglandin f2alpha 20-Hydroxy-3,4-seco-5α-dammara-4(28),24-dien-3-oic acid 15-Cyclohexyl pentanor prostaglandin f2alpha CARBACYCLIN