Quinacrine mustard dihydrochloride manufacturers
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| | Quinacrine mustard dihydrochloride Basic information |
| Product Name: | Quinacrine mustard dihydrochloride | | Synonyms: | 9-(4-bis(2-chloroethyl)amino-1-methylbutylamino)-6-chloro-2-methoxy-acridin;9-(4-bis(2-chloroethyl)amino-1-methylbutylamino)-6-chloro-2-methoxyacridine;icr10;quinacrinemustard;N1,N1-bis(2-chloroethyl)-N4-(6-chloro-2-methoxyacridin-9-yl)pentane-1,4-diamine dihydrochloride;QUINACRINE MUSTARD DIHYDROCHLORIDE, FOR FLUORESCENCE;QUINACRINE MUSTARD DIHYDROCHLORIDE 90+%;2-methoxy-6-chloro-9-(4-bis[β-chloroethyl]amino-1-methylbutylamino)acridine dihydrochloride | | CAS: | 4213-45-0 | | MF: | C23H30Cl5N3O | | MW: | 541.77 | | EINECS: | 224-140-9 | | Product Categories: | | | Mol File: | 4213-45-0.mol |  |
| | Quinacrine mustard dihydrochloride Chemical Properties |
| storage temp. | −20°C | | solubility | Chloroform: soluble | | form | A crystalline solid | | color | Light yellow to yellow | | Water Solubility | Water: soluble | | BRN | 3819822 | | InChI | 1S/C23H28Cl3N3O.2ClH/c1-16(4-3-11-29(12-9-24)13-10-25)27-23-19-7-5-17(26)14-22(19)28-21-8-6-18(30-2)15-20(21)23;;/h5-8,14-16H,3-4,9-13H2,1-2H3,(H,27,28);2*1H | | InChIKey | JETDZFFCRPFPDH-UHFFFAOYSA-N | | SMILES | C1(NC(C)CCCN(CCCl)CCCl)C2C=CC(Cl)=CC=2N=C2C=CC(OC)=CC=12.Cl.Cl | | CAS DataBase Reference | 4213-45-0 | | EPA Substance Registry System | 1,4-Pentanediamine, N1,N1-bis(2-chloroethyl)-N4-(6-chloro-2-methoxy-9-acridinyl)-, dihydrochloride (4213-45-0) |
| Hazard Codes | T | | Risk Statements | 46-23/25-42/43 | | Safety Statements | 53-22-36/37/39-45 | | RIDADR | 3249 | | WGK Germany | 3 | | RTECS | AR7580000 | | TSCA | TSCA listed | | HazardClass | 6.1(b) | | PackingGroup | III | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Repr. 2
Resp. Sens. 1
Skin Sens. 1 |
| | Quinacrine mustard dihydrochloride Usage And Synthesis |
| Description | Quinacrine mustard is a fluorescent DNA-intercalating agent. It selectively binds to adenine-thymine (AT) base pairs over guanine-cytosine (GC) base pairs. Quinacrine mustard has been used to label metaphase chromosomes for karyotyping by autoradiography. It displays excitation/emission maxima of 425/480 nm, respectively. | | Uses | Quinacrine mustard dihydrochloride is a fluorescent probe. | | Safety Profile | Questionable carcinogen with experimental neoplastigenic data. Human mutation data reported. Corrosive. When heated to decomposition it emits very toxic fumes of Cland NOx. See also QUINACRINE MUSTARD. | | References | [1] T. CASPERSSON . Chemical differentiation along metaphase chromosomes[J]. Experimental cell research, 1968, 49 1: Pages 219-222. DOI: 10.1016/0014-4827(68)90538-7
[2] J R ELLISON H J B. Quinacrine fluorescence of specific chromosome regions. Late replication and high A: T content in Samoaia leonensis.[J]. Chromosoma, 1972, 36 4: 375-390. DOI: 10.1007/bf00336794
[3] B WEISBLUM P L D H. Quinacrine, a chromosome stain specific for deoxyadenylate-deoxythymidylaterich regions in DNA.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1972, 69 3: 629-632. DOI: 10.1073/pnas.69.3.629
[4] CHEN R F. Fluorescence of quinacrine mustard conjugated to proteins[J]. Archives of biochemistry and biophysics, 1976, 172 1: Pages 39-50. DOI: 10.1016/0003-9861(76)90045-x |
| | Quinacrine mustard dihydrochloride Preparation Products And Raw materials |
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