DFMO manufacturers
- L-Eflornithine
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- $1520.00
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2026-05-11
- CAS:66640-93-5
- Purity:
- Supply Ability: 10g
- L-Eflornithine
-
- $1520.00
-
2025-08-22
- CAS:66640-93-5
- Purity:
- Supply Ability: 10g
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| Product Name: | DFMO | | Synonyms: | ALPHA-DIFLUORO-ME-DL-ORNITHINE;ALPHA-DIFLUOROMETHYL-DL-ORNITHINE;L-alpha-Difluoromethylornithine;DFMO;DL-ALPHA-DIFLUOROMETHYLORNITHINE;H-DL-(F2ME)ORN-OH;H-DL-(ALPHA-DIFLUOROMETHYL)ORN-OH;H-ALPHA-DIFLUORO-ME-DL-ORN-OH | | CAS: | 66640-93-5 | | MF: | C6H12F2N2O2 | | MW: | 182.17 | | EINECS: | | | Product Categories: | | | Mol File: | 66640-93-5.mol |  |
| Boiling point | 347.0±42.0 °C(Predicted) | | density | 1.293±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 1.22±0.44(Predicted) |
| Uses | L-Eflornithine (L-DFMO) is an enantiomer of Eflornithine. L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with a KD of 1.3±0.3 μM, and a Kinact of 0.15±0.03 min-1[1]. | | Biological Activity | L-Eflornithine (L-DFMO) is the enantiomer of Eflornithine. L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with KD of 1.3±0.3 μM and Kinact of 0.15±0.03 min-1. | | in vivo | The more potent L-Eflornithine is present at much lower concentrations in both plasma and cerebrospinal fluid (CSF) than those of the D-Eflornithine. The plasma concentrations of L-Eflornithine are on average 52% of the D -enantiomer concentrations. The typical oral clearances of L-Eflornithine and D-eflornithine are 17.4 and 8.23 liters/h, respectively. | | target | KD: 1.3±0.3 μM (Ornithine decarboxylase, ODC) | | References | [1] Qu N, et al. Inhibition of human ornithine decarboxylase activity by enantiomers of difluoromethylornithine. Biochem J. 2003 Oct 15;375(Pt 2):465-70. DOI:10.1042/BJ20030382
[2] Jansson-Lfmark R, et al. Enantiospecific reassessment of the pharmacokinetics and pharmacodynamics of oral eflornithine against late-stage Trypanosoma brucei gambiense sleeping sickness. Antimicrob Agents Chemother. 2015 Feb;59(2):1299-307. DOI:10.1128/AAC.04101-14 |
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