- Muscone
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- $85.00
-
2026-05-28
- CAS:541-91-3
- Min. Order: 1KG
- Purity: 99.%
- Supply Ability: 10 ton
- Muscone
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- $39.00
-
2026-05-11
- CAS:541-91-3
- Purity: 98.97%
- Supply Ability: 10g
- Muscone
-
- $10.00
-
2026-03-20
- CAS:541-91-3
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 mt
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| | Muscone Basic information |
| | Muscone Chemical Properties |
| Melting point | -15°C(lit.) | | Boiling point | 95°C/0.1mmHg(lit.) | | density | 0.9221 | | vapor pressure | 0.041Pa at 25℃ | | FEMA | 3434 | 3-METHYL-1-CYCLOPENTADECANONE | | refractive index | 1.4770 to 1.4810 | | RTECS | GY0950000 | | storage temp. | Sealed in dry,Room Temperature | | solubility | Chloroform, Methanol (Sparingly) | | form | Colorless oil. | | color | Colourless | | Odor | at 10.00 % in dipropylene glycol. sweet musk animal powdery fatty natural | | Odor Type | musk | | biological source | mouse | | Water Solubility | 430μg/L at 20℃ | | λmax | 285nm(EtOH)(lit.) | | Merck | 14,6313 | | JECFA Number | 1402 | | Major Application | food and beverages | | Cosmetics Ingredients Functions | PERFUMING | | InChI | 1S/C16H30O/c1-15-12-10-8-6-4-2-3-5-7-9-11-13-16(17)14-15/h15H,2-14H2,1H3 | | InChIKey | ALHUZKCOMYUFRB-UHFFFAOYSA-N | | SMILES | O=C1CC(CCCCCCCCCCCC1)C | | LogP | 6.06 at 25℃ | | CAS DataBase Reference | 541-91-3(CAS DataBase Reference) | | NIST Chemistry Reference | Cyclopentadecanone, 3-methyl-(541-91-3) | | EPA Substance Registry System | Cyclopentadecanone, 3-methyl- (541-91-3) |
| | Muscone Usage And Synthesis |
| Chemical Properties | Muscone is an odoriferous constituent
of natural musk. It is a colorless liquid with very soft, sweet, musky odor
and a perfumery, animal tonality.Numerous syntheses have been developed for its
preparation including enantioselective methods to obtain the naturally occurring
(3R)-enantiomer (l-muscone,.
Because of its excellent stability, it can be used in awide range of products to give
elegant,warm, animal notes. It is important for the reconstitution of naturalmusk. | | Chemical Properties | Musk is secreted exclusively by the male animals of Moschus moschiferus, a
wild deer living in themountains of Nepal,Tibet, and Mongolia.Thelight yellow
secretion with a salve consistency accumulates in the abdominal pouch
and probably serves to attract the females. When the pouch is dried, the
secretion solidifies to form a brittle, brown mass with a characteristic odor.
Since several Moschus species occur, large variations exist in the quality and
specifications of musk. Hunting of the animals has been prohibited; therefore,
only small quantities ofmusk are occasionally offered at extremely high
prices. In the United States and Europe, naturalmusk is no longer used
as a fragrance ingredient. | | Chemical Properties | 3-Methyl-1-cyclopentadecanone has a soft, sweet, tenacious, musky odor. | | Chemical Properties | Colorless oily liquid | | Occurrence | Reported found in natural musk | | Uses | Muscone protects PC12 cells against glutamate-induced apoptosis. | | Preparation | From condensation of dodecamethyl-ene-α,ω-dimethylketone hexadecane. | | Aroma threshold values | Detection: 9.8 ppb | | Synthesis Reference(s) | The Journal of Organic Chemistry, 45, p. 1906, 1980 DOI: 10.1021/jo01298a029
Tetrahedron Letters, 17, p. 2617, 1976 | | Flammability and Explosibility | Not classified | | Biological Activity | muscone is a potent anti-inflammatory agent, which has been implicated in reducing proinflammatory cytokines and end-plate degeneration [1]. muscone is a territorial releaser pheromone in moschus moschiferus. muscone is not produced by humans. muscone is animal pheromone with no effects on humans comparable to those of androstadienone [2]. (±)-muscone is an odoriferous constituent of musk, a glandular secretion originally collected from the male musk deer [3]. | | Safety Profile | Low oral and skin
contact toxicity. A skin irritant. A flammable
liquid. When heated to decomposition it
emits acrid smoke and irritating fumes. | | Synthesis | Starting from propargyl alcohol and 1,12-dibromododecane, a long-chain ω-acetaldehyde intermediate was constructed via alkylation. Subsequently, a key asymmetric macrocyclization reaction was carried out using a chiral amino alcohol ligand to close the chain molecule and introduce a chiral center. Finally, Muscone with the native configuration was efficiently synthesized by catalytic hydrogenation reduction of the double bond. | | in vitro | muscone reversed il-1β-induced upregulation of il-1β, tumor necrosis factor α, cyclooxygenase 2, inducible nitric oxide synthase, matrix metalloproteinase 13, aggrecanase 2, and nitric oxide and downregulation of col2α1 and aggrecan. in end-plate cartilage cultures, pretreatment with muscone (6.25, 12.5, 25 μmol/l) inhibited the il-1β-induced phosphorylation of extracellular signal-regulated kinases 1/2 and c-jun n-terminal kinase in a dose-dependent manner [1]. | | in vivo | in a rat model with induced intervertebral disc degeneration, muscone inhibited the expression of prostaglandin e2, 6-keto-prostaglandin f1α, il-1β, and tumor necrosis factor α and recovered the structural distortion of the degenerative disc [1]. | | References | [1] liang q q, zhang m, zhou q, et al. muscone protects vertebral end-plate degeneration by antiinflammatory property[j]. clinical orthopaedics and related research, 2010, 468(6): 1600-1610.
[2] jacob s, garcia s, hayreh d, et al. psychological effects of musky compounds: comparison of androstadienone with androstenol and muscone[j]. hormones and behavior, 2002, 42(3): 274-283.
[3] fujimoto, s. ,yoshikawa, k.,itoh, m., et al. synthesis of (r)- and (s)- muscone. bioscience, biotechnology, and biochemistry 66(6), 1389-1392 (2002).
[4] WOLFGANG OPPOLZER Rumen N R. Synthesis of (R)-(-)-muscone by an asymmetrically catalyzed macrocyclization of an .omega.-alkynal[J]. Journal of the American Chemical Society, 1993, 115 4: 1593-1594. DOI:10.1021/ja00057a064. |
| | Muscone Preparation Products And Raw materials |
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