| Company Name: |
Energy Chemical |
| Tel: |
400-0056266 |
| Email: |
marketing1@energy-chemical.com |
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| | trans-Cevimeline Hydrochloride Basic information |
| Product Name: | trans-Cevimeline Hydrochloride | | Synonyms: | (2S)-2-methylspiro[1,3-oxathiolane-5,3'-1-azabicyclo[2.2.2]octane]:hydrochloride;Cevimeline Impurity 7(trans-Cevimeline HCl);trans-Cevimeline HCl;rac,trans-Cevimeline Hydrochloride;AF 102A HCl;Cevimeline Impurity | | CAS: | 107220-29-1 | | MF: | C10H18ClNOS | | MW: | 235.77402 | | EINECS: | | | Product Categories: | | | Mol File: | 107220-29-1.mol |  |
| | trans-Cevimeline Hydrochloride Chemical Properties |
| solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Solid | | color | White to Off-White | | Stability: | Hygroscopic |
| | trans-Cevimeline Hydrochloride Usage And Synthesis |
| Description | trans-Cevimeline HCl, also known as AF 102A, is the trans-isomer of AF102B (Cevimeline). Cevimeline is a cholinergic analogue with glandular secretion stimulatory activity. Cevimeline binds to and activates muscarinic receptors, thereby increasing the secretions in exocrine salivary and sweat glands. This cholinergic agonist also increases the tone of smooth muscle in the gastrointestinal and urinary tracts. Cevimeline is being studied as a treatment for dry mouth caused by radiation therapy to the head and neck. | | Uses | trans-Cevimeline Hydrochloride is a reagent in the preparation of spiro-oxathiolane/quinuclidine sulfoxide derivative for the treatment of central nervous and cholinergic system disease or disorders. | | in vivo | AF102A (1 mg/kg; i.p.) reverses cognitive impairments in a step-through passive avoidance task[1].
| Animal Model: | Rats[1] | | Dosage: | 1 mg/kg | | Administration: | I.p. | | Result: | Reversed cognitive impairments in a step-through passive avoidance task. |
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| | trans-Cevimeline Hydrochloride Preparation Products And Raw materials |
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