(LEU31,PRO34)-NEUROPEPTIDE Y (HUMAN, RAT)

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(LEU31,PRO34)-NEUROPEPTIDE Y (HUMAN, RAT) Basic information
Product Name:(LEU31,PRO34)-NEUROPEPTIDE Y (HUMAN, RAT)
Synonyms:TYR-PRO-SER-LYS-PRO-ASP-ASN-PRO-GLY-GLU-ASP-ALA-PRO-ALA-GLU-ASP-MET-ALA-ARG-TYR-TYR-SER-ALA-LEU-ARG-HIS-TYR-ILE-ASN-LEU-LEU-THR-ARG-PRO-ARG-TYR-NH2;YPSKPDNPGEDAPAEDMARYYSALRHYINLLTRPRY-NH2;H-TYR-PRO-SER-LYS-PRO-ASP-ASN-PRO-GLY-GLU-ASP-ALA-PRO-ALA-GLU-ASP-MET-ALA-ARG-TYR-TYR-SER-ALA-LEU-ARG-HIS-TYR-ILE-ASN-LEU-LEU-THR-ARG-PRO-ARG-TYR-NH2;[LEU31,PRO34] NEUROPEPTIDE Y, HUMAN;(LEU31,PRO34)-NEUROPEPTIDE Y (HUMAN, RAT);[LEU31,PRO34] NPY, HUMAN;(LEU31,PRO34)-NPY (HUMAN, RAT);M.W. 4240.67 C189H284N54O56S
CAS:132699-73-1
MF:C189H284N54O56S
MW:4240.67046
EINECS:
Product Categories:Neuropeptide Y (NPY ) receptor;peptide
Mol File:132699-73-1.mol
(LEU31,PRO34)-NEUROPEPTIDE Y (HUMAN, RAT) Structure
(LEU31,PRO34)-NEUROPEPTIDE Y (HUMAN, RAT) Chemical Properties
storage temp. −20°C
solubility Soluble in DMSO
form Powder
Water Solubility Soluble to 1 mg/ml in water
SequenceTyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Leu-Thr-Arg-Pro-Arg-Tyr-NH2
Safety Information
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
(LEU31,PRO34)-NEUROPEPTIDE Y (HUMAN, RAT) Usage And Synthesis
Uses[Leu31,Pro34]-Neuropeptide Y(human,rat) is a specific neuropeptide Y Y1 receptor agonist. [Leu31,Pro34]-Neuropeptide Y(human,rat) slao activates Y4, Y5. [Leu31,Pro34]-Neuropeptide Y(human,rat) can increase blood pressure in anesthetized rats and increases food intake[1][2].
in vivo

[Leu31,Pro34]-Neuropeptide Y(human,rat) (30 pmol; microinjected into paraventricular nucleus) increases food intake in the rats (350±400 g)[3].

IC 50NPY Y1 receptor; NPY Y4 receptor; NPY Y5 receptor
storageStore at -20°C
References[1] J Fuhlendorff, et al. [Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist. Proc Natl Acad Sci U S A. 1990 Jan;87(1):182-6. DOI:10.1073/pnas.87.1.182
[2] K McCrea, et al. 2-36[K4,RYYSA(19-23)]PP a novel Y5-receptor preferring ligand with strong stimulatory effect on food intake. Regul Pept. 2000 Feb 8;87(1-3):47-58. DOI:10.1016/s0167-0115(99)00108-1
[3] A Kask, et al. Evidence for involvement of neuropeptide Y receptors in the regulation of food intake: studies with Y1-selective antagonist BIBP3226. Br J Pharmacol. 1998 Aug;124(7):1507-15. DOI:10.1038/sj.bjp.0701969
(LEU31,PRO34)-NEUROPEPTIDE Y (HUMAN, RAT) Preparation Products And Raw materials
Tag:(LEU31,PRO34)-NEUROPEPTIDE Y (HUMAN, RAT)(132699-73-1) Related Product Information
NEUROPEPTIDE Y (HUMAN, RAT) NEUROPEPTIDE FF GALANIN, PORCINE NEUROPEPTIDE F Galanin (1-16), mouse, porcine, rat TFA Calcitonin Gene Related Peptide (CGRP) (83-119), rat TFA substance P (3-11) NEUROPEPTIDE Y (13-36), PORCINE SYNTHETI C >97% Substance P (1-7)(TFA) PANCREATIC POLYPEPTIDE, RAT SUBSTANCE P Substance P, Free Acid Gly-Leu-Met-NH2 Substance P (6-11) Substance P (1-9) Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-OMe Substance P (2-11) H-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2