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| | 5-PHENYL-1H-PYRROLE-2-CARBOXYLIC ACID Basic information |
| Product Name: | 5-PHENYL-1H-PYRROLE-2-CARBOXYLIC ACID | | Synonyms: | TIMTEC-BB SBB000262;5-PHENYL-1H-PYRROLE-2-CARBOXYLIC ACID;1H-Pyrrole-2-carboxylic acid, 5-phenyl-;5-Phenyl-1H-pyrrole-2-carboxilyc acid;5-Phenylpyrrole-2-carboxylic Acid | | CAS: | 6636-06-2 | | MF: | C11H9NO2 | | MW: | 187.19 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | 5-PHENYL-1H-PYRROLE-2-CARBOXYLIC ACID Chemical Properties |
| Melting point | 206-208 °C (decomp) | | Boiling point | 452.3±33.0 °C(Predicted) | | density | 1.285±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 4.45±0.10(Predicted) | | Appearance | Off-white to pale purple Solid |
| Hazard Codes | Xi,Xn | | Risk Statements | 22 | | HazardClass | IRRITANT |
| | 5-PHENYL-1H-PYRROLE-2-CARBOXYLIC ACID Usage And Synthesis |
| Synthesis | 5-Phenylpyrrole-2-carboxylate (20 mg, 0.09 mmol) was dissolved in a solvent mixture of 1 mL of tetrahydrofuran, 0.5 mL of methanol and 0.5 mL of water. After stirring at room temperature, LiOH (4 mg, 0.18 mmol) was added. Stirring was continued at room temperature for 2 h. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming that the reaction was complete, the solvent was removed using a rotary evaporator. Ice water was added to the reaction residue, which was then acidified with 1 M HCl solution to the appropriate pH and the precipitate was collected by filtration to afford 5-phenyl-1H-pyrrole-2-carboxylic acid (10 mg, 59% yield). | | References | [1] Patent: CN107151255, 2017, A. Location in patent: Paragraph 0244; 0245; 0246
[2] Magnetic Resonance in Chemistry, 2009, vol. 47, # 12, p. 1101 - 1109 |
| | 5-PHENYL-1H-PYRROLE-2-CARBOXYLIC ACID Preparation Products And Raw materials |
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