tert-Butyl N-[5-(tosyloxy)pentyl]carbamate

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tert-Butyl N-[5-(tosyloxy)pentyl]carbamate Basic information
Product Name:tert-Butyl N-[5-(tosyloxy)pentyl]carbamate
Synonyms:TERT-BUTYL 5-TOSYLHYDROXYPENTYLCARBAMATE;Carbamic acid,[5-[[(4-methylphenyl)sulfonyl]oxy]pentyl]-, 1,1-dimethylethyl ester (9CI);[5-[[(4-Methylphenyl)sulfonyl]oxy]pentyl]carbaMic Acid 1,1-DiMethylethyl Ester;Carbamic acid, N-[5-[[(4-methylphenyl)sulfonyl]oxy]pentyl]-, 1,1-dimethylethyl ester;N-[5-(methylbenzenesulfonyl)pentyl]aminomacetic acidtertbutyl ester;5-((tert-butoxycarbonyl)amino)pentyl 4-methylbenzenesulfonate;tert-Butyl N-[5-(tosyloxy)pentyl]carbamate
CAS:118811-34-0
MF:C17H27NO5S
MW:357.47
EINECS:
Product Categories:Aromatices;Sulfur & Selenium Compounds;Aromatices, Sulfur & Selenium Compounds
Mol File:118811-34-0.mol
tert-Butyl N-[5-(tosyloxy)pentyl]carbamate Structure
tert-Butyl N-[5-(tosyloxy)pentyl]carbamate Chemical Properties
Melting point 47-49°C
Boiling point 501.854±33.00 °C(Press: 760.00 Torr)(predicted)
density 1.136±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp. Refrigerator
solubility Chloroform (Slightly), Methanol (Slightly)
pka12.866±0.46(predicted)
form Solid
color White
Safety Information
MSDS Information
tert-Butyl N-[5-(tosyloxy)pentyl]carbamate Usage And Synthesis
Description5-((tert-Butoxycarbonyl)amino)pentyl 4-methylbenzenesulfonate is a PEG linker containing a Boc protected amine and a tosyl group. The protected amine can be deprotected under mild acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.
Chemical PropertiesWhite Solid
Uses5-((tert-Butoxycarbonyl)amino)pentyl 4-methylbenzenesulfonate is a PEG linker containing a Boc protected amine and a tosyl group. The protected amine can be deprotected under mild acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions.
tert-Butyl N-[5-(tosyloxy)pentyl]carbamate Preparation Products And Raw materials
Raw materialsTosyl chloride-->5-(Boc-amino)-1-pentanol-->p-Toluenesulfonic acid
Preparation Products(5-Azidopentyl)carbaMic acid tert-butyl ester
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