马来酸哌克昔林
| 中文名称 | 马来酸哌克昔林 |
|---|---|
| 中文同义词 | 马来酸哌西林;马来酸哌克昔林;2-(2,2-二环己基乙基)哌啶 马来酸盐;哌克昔林 马来酸盐;RAC 马来酸哌克昔林;马来酸哌克昔林,10 MM DMSO 溶液;肉碱棕榈酰转移酶1抑制剂(PERHEXILINE MALEATE);Perhexiline maleate试剂 |
| 英文名称 | PERHEXILINE MALEATE SALT |
| 英文同义词 | 2-(2,2-dicyclohexylethyl)piperidinemaleate;2-(2,2-dicyclohexylethyl)-piperidinmaleate(1:1);perhexilinemaleate;perhexilene maleate;Pexid;WSM-3978;rac Perhexiline Maleate;2-(2,2-dicyclohexylethyl)piperidinium hydrogen maleate |
| CAS号 | 6724-53-4 |
| 分子式 | C23H39NO4 |
| 分子量 | 393.56 |
| EINECS号 | 229-775-5 |
| 相关类别 | 细胞生物学试剂;医药原料;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;THENYLENE |
| Mol文件 | 6724-53-4.mol |
| 结构式 |  |
马来酸哌克昔林 性质
| 熔点 | 181-183°C |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：≥5mg/mL |
| 形态 | 粉末 |
| 颜色 | 白色至棕褐色 |
| InChI | 1S/C19H35N.C4H4O4/c1-3-9-16(10-4-1)19(17-11-5-2-6-12-17)15-18-13-7-8-14-20-18;5-3(6)1-2-4(7)8/h16-20H,1-15H2;1-2H,(H,5,6)(H,7,8)/b;2-1- |
| InChIKey | JDZOTSLZMQDFLG-BTJKTKAUSA-N |
| SMILES | OC(=O)\C=C/C(O)=O.C1CCC(CC1)C(CC2CCCCN2)C3CCCCC3 |
Perhexiline maleate 是一种有效的 carnitine palmitoyltransferase 1 (CPT1) 的抑制剂，对大鼠心脏CPT1和肝脏CPT1的IC50值分别为77 μM和148 μM。
| Target | Value |
|
rat heart CPT1
(Cell-free assay) | 77 μM |
|
rat liver CPT1
(Cell-free assay) | 148 μM |
At 24, 48 and 72 h of treatment with 0.01 and 1 μM of Perhexiline , NDM29 ncRNA expression level in SH-SY5Y cells is progressively increased, reaching a peak after 48 hours of treatment. Perhexiline treatment increases the susceptibility of NB cells to antiblastic treatments. Co-administration of Perhexiline maleate potentiates the efficacy of cisplatin to reduce the in vitro clonogenic potential of NB cells.
The co-administration of Perhexiline and cisplatin yields a clear enhancement of antitumor effects, resulting in a significantly improved progression-free survival as compared with mice treated with DMSO. Perhexiline favors NB cell transition to differentiated phenotype.
安全信息
| WGK Germany | 2 |
|---|---|
| RTECS号 | TM7068000 |
| 存储类别 | 11 - 可燃固体 |
| 毒性 | LD50 in rats, mice (g/kg): >7, 4.37 orally (Causa, Perri) |
| 提供商 | 语言 |
|---|---|
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英文
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