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BOC Sciences
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16314854226 |
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Product Name:XL413 hydrochloride
CAS:2062200-97-7
Purity:98% Package:1G;10G;100G Remarks:XL413 is a potent and selective inhibitor of Cdc7 with IC50 value of 3.4 nM. It exhibits >60, >10, and >300-fold selectivity for Cdc7 over CK2, PIM1, and a panel of over 100 protein kinases, respectiv
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Shanghai Rechem science Co., Ltd.
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021-31433387 15618786686 |
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sales@rechemscience.com |
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CAS:2062200-97-7
Purity:98% Package:100mg
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Beijing Jin Ming Biotechnology Co., Ltd.
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010-60605840 18892239720 |
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psaitong@jm-bio.com |
| Products Intro: |
Product Name:XL413 hydrochloride
CAS:2062200-97-7
Purity:98% Package:5mg;10mg;50mg
|
XL413 (hydrochloride) manufacturers
- XL413 hydrochloride
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- $48.00 / 1mg
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2025-11-10
- CAS:2062200-97-7
- Min. Order:
- Purity: 99.82%
- Supply Ability: 10g
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| | XL413 (hydrochloride) Basic information |
| | XL413 (hydrochloride) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO:0.2(Max Conc. mg/mL);0.613(Max Conc. mM)
PBS (pH:7.2):10.0(Max Conc. mg/mL);30.66(Max Conc. mM) | | form | A crystalline solid | | color | White to off-white |
| | XL413 (hydrochloride) Usage And Synthesis |
| Description | XL413 is a potent inhibitor of Cdc7 (IC50 = 3.4 nM). It is >60, >10, and >300-fold selective for Cdc7 over CK2, PIM1, and a panel of over 100 protein kinases, respectively. XL413 inhibits the growth of MDA-MB-231T and COLO 205 cells (IC50s = 118 and 140 nM, respectively). It inhibits Cdc7-specific phosphorylation of mini-chromosome maintenance protein (MCM2) and induces cell cycle accumulation in the S and G2 phases in MDA-MB-231T and COLO 205 cells that overexpress Cdc7. In vivo, XL413 inhibits MCM2 phosphorylation (ED50 = <3 mg/kg) and reduces tumor growth in a COLO 205 mouse xenograft model when administered orally at doses of 10, 30, and 100 mg/kg. | | Uses | XL413 (BMS-863233) hydrochloride is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC50 of 3.4 nM, and also shows potent effect with IC50s of 215, 42 nM on CK2, PIM1, respectively, and an EC50 of 118 nM on pMCM. | | in vivo | XL413 (BMS-863233; 100 mg/kg, p.o.) hydrochloride shows excellent plasma exposures in mice and possesses good PK properties. XL413 (10, 30, or 100 mg/kg, p.o.) hydrochloride is well tolerated at all the doses, with no significant body weight loss[1]. | | IC 50 | Cdc7: 3.4 nM (IC50); PIM1: 42 nM (IC50); CK2: 215 nM (IC50) | | References | [1] Koltun ES, et al. Discovery of XL413, a potent and selective CDC7 inhibitor. Bioorg Med Chem Lett. 2012 Jun 1;22(11):3727-31. DOI:10.1016/j.bmcl.2012.04.024
[2] Sasi NK, et al. The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds. PLoS One. 2014 Nov 20;9(11):e113300. DOI:10.1371/journal.pone.0113300 |
| | XL413 (hydrochloride) Preparation Products And Raw materials |
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