BMS-908662

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Company Name: Chengdu Novel Biomedical Co., Ltd.  
Tel: 028-85255396 18302801538
Email: cdnovell@163.com
Company Name: BOC Sciences  
Tel: 16314854226; +8616314854226
Email: inquiry@bocsci.com
Company Name: TargetMol Chemicals Inc.  
Tel: +1-781-999-5354; +1-00000000000
Email: marketing@targetmol.com
Company Name: Chunchuang (Wuhan) Technology Co., Ltd  
Tel: 15727060112
Email: yutianchun2007@126.com
Company Name: TargetMol Chemicals Inc.  
Tel: 4008200310 15002144251
Email: marketing@tsbiochem.com

BMS-908662 manufacturers

  • Xl-281
  • Xl-281 pictures
  • $293.00
  • 2026-07-27
  • CAS:870603-16-0
  • Purity: 99.12%
  • Supply Ability: 10g
BMS-908662 Basic information
Product Name:BMS-908662
Synonyms:BMS-908662;Carbamic acid, N-[6-[2-(5-chloro-2-methylphenyl)-2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl]-1H-benzimidazol-2-yl]-, methyl ester;BMS-908662(1X-281)
CAS:870603-16-0
MF:C24H19ClN4O4
MW:462.89
EINECS:
Product Categories:
Mol File:870603-16-0.mol
BMS-908662 Structure
BMS-908662 Chemical Properties
density 1.526±0.06 g/cm3(Predicted)
pka10.77±0.20(Predicted)
Safety Information
MSDS Information
BMS-908662 Usage And Synthesis
UsesXL-281 (BMS-908662) is an orally active inhibitor for RAF kinase, with IC50s of 2.6, 4.5 and 6 nM, for CRAF, B-RAF, and B-RAFV600E, respectively. XL-281 exhibits antitumor activity[1].
IC 50c-Raf: 2.6 nM (IC50); B-Raf: 4.5 nM (IC50); B-RafV600E: 6 nM (IC50)
References[1] Dickson MA, et al., Phase I study of XL281 (BMS-908662), a potent oral RAF kinase inhibitor, in patients with advanced solid tumors. Invest New Drugs. 2015 Apr;33(2):349-56. DOI:10.1007/s10637-014-0191-5
BMS-908662 Preparation Products And Raw materials
Tag:BMS-908662(870603-16-0) Related Product Information
XL 228 XL-019 XL413 (hydrochloride) 3-Acridinecarboxamide, 9-chloro-5,6,7,8-tetrahydro-N-[(4S)-5-[4-hydroxy-4-[[7-[[3-(4-methyl-1-piperazinyl)-1-oxopropyl]amino]-4-oxo-3(4H)-quinazolinyl]methyl]-1-piperidinyl]-5-oxo-4-(phenylmethyl)pentyl]- XL-388 XL888 XL765 2-methoxyethyl 4-((4-(4-chlorophenoxy)-3,5-difluorophenyl)sulfonyl)-3-(hydroxycarbamoyl)piperazine-1-carboxylate