TP0427736 manufacturers
- TP0427736
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- $97.00
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2026-07-27
- CAS:864374-00-5
- Purity: 97.67%
- Supply Ability: 10g
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| | TP0427736 Basic information |
| Product Name: | TP0427736 | | Synonyms: | TP0427736;TP0427736 HCl;TP427736;TP-427736;Benzothiazole, 6-[5-(4-methyl-2-thiazolyl)-1H-imidazol-4-yl]-;TP0427736, 10 mM in DMSO;6-[5-(4-Methyl-1,3-thiazol-2-yl)-1H-imidazol-4-yl]-1,3-benzothiazole | | CAS: | 864374-00-5 | | MF: | C14H10N4S2 | | MW: | 298.39 | | EINECS: | | | Product Categories: | | | Mol File: | 864374-00-5.mol |  |
| | TP0427736 Chemical Properties |
| Boiling point | 634.7±65.0 °C(Predicted) | | density | 1.439±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 67 mg/mL (200.09 mM);Ethanol: Insoluble | | pka | 9.70±0.10(Predicted) | | Water Solubility | Water: Insoluble |
| | TP0427736 Usage And Synthesis |
| Uses | TP0427736 is a selective inhibitor of ALK5 with an IC50 of 2.72 nM. TP0427736 inhibits Smad2/3 phosphorylation in A549 cells. TP0427736 decreases the growth inhibition of human outer root sheath cells[1]. | | Biological Activity | TP0427736 is a potent ALK5 kinase inhibitor with IC50 of 2.72 nM and IC50 of 836 nM for ALK3. It also inhibits TGF-β1-induced phosphorylation of Smad2/3 in A549 cells with IC50 of 8.68 nM. | | in vitro | TP0427736 can inhibit Smad2/3 phosphorylation in a concentration-dependent manner with IC50 of 8.68 nM. In outer root sheath cells, it rescued the inhibition of cell proliferation by TGF-β1 and TGF-β2. | | in vivo | TP0427736 reduces hair follicle length shortening during the transition from anagen to catagen. | | target | | Target | Value | ALK5
(Cell-free assay) | 2.72 nM |
| | References | [1] Naruse T, et al. Novel ALK5 inhibitor TP0427736 reduces TGF-βinduced growth inhibition in human outer root sheath cells and elongates anagen phase in mouse hair follicles. Pharmacol Rep. 2017 Jun;69(3):485-491. DOI:10.1016/j.pharep.2017.01.024 |
| | TP0427736 Preparation Products And Raw materials |
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