| Company Name: |
DC Chemicals |
| Tel: |
021-58447131 13564518121 |
| Email: |
doncunbiosci@gmail.com |
|
| Product Name: | MC3343 | | Synonyms: | MC3343;MC-3343;MC 3343;Benzamide, N-[3-[(2-amino-6-methyl-4-pyrimidinyl)amino]phenyl]-3-(4-quinolinylamino)-;N-(3-(2-Amino-6-methylpyrimidin-4-ylamino)phenyl)-3-(quinolin-4-ylamino)benzamide | | CAS: | 1535187-91-7 | | MF: | C27H23N7O | | MW: | 461.52 | | EINECS: | | | Product Categories: | | | Mol File: | 1535187-91-7.mol |  |
| | MC3343 Chemical Properties |
| solubility | DMSO: Sparingly Soluble: 1-10 mg/mL |
| | MC3343 Usage And Synthesis |
| Uses | MC3343, a DNMT inhibitor (EC50 of 5.7 μM) and a strong DNA binder, affects tumor proliferation by blocking OS cells in G1 or G2/M phases and induces osteoblastic differentiation through the specific re-expression of genes regulating this physiological process[1]. | | References | [1] Maria Cristina Manara, et al. A Quinoline-Based DNA Methyltransferase Inhibitor as a Possible Adjuvant in Osteosarcoma Therapy. Mol Cancer Ther. 2018 Sep;17(9):1881-1892. DOI:10.1158/1535-7163.MCT-17-0818
[2] SERGIO VALENTE. Selective Non-nucleoside Inhibitors of Human DNA Methyltransferases Active in Cancer Including in Cancer Stem Cells[J]. Journal of Medicinal Chemistry, 2014, 57 3: 701-713. DOI: 10.1021/jm4012627 |
| | MC3343 Preparation Products And Raw materials |
|