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RORγt inhibitor 1 manufacturers
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| | RORγt inhibitor 1 Basic information |
| Product Name: | RORγt inhibitor 1 | | Synonyms: | RORγt inhibitor 1;RORγt Inverse agonist 8;(S)-N-(8-((4-(cyclopentanecarbonyl)-3-methylpiperazin-1-yl)methyl)-7-methylimidazo[1,2-a]pyridin-6-yl)-2-methylpyrimidine-5-carboxamide;5-Pyrimidinecarboxamide, N-[8-[[(3S)-4-(cyclopentylcarbonyl)-3-methyl-1-piperazinyl]methyl]-7-methylimidazo[1,2-a]pyridin-6-yl]-2-methyl-;N-[8-[[(3S)-4-(Cyclopentylcarbonyl)-3-methyl-1-piperazinyl]methyl]-7-methylimidazo[1,2-a]pyridin-6-yl]-2-methyl-5-pyrimidinecarboxam ide;RORγt Inverse agonist 8 | | CAS: | 2079892-79-6 | | MF: | C26H33N7O2 | | MW: | 475.59 | | EINECS: | | | Product Categories: | | | Mol File: | 2079892-79-6.mol |  |
| | RORγt inhibitor 1 Chemical Properties |
| density | 1.35±0.1 g/cm3(Predicted) | | pka | 10.15±0.46(Predicted) |
| | RORγt inhibitor 1 Usage And Synthesis |
| Description | GKN92796, also known as RORγt inhibitor 1, is a RORγt inhibitor. This product has no formal name at the moment. | | Uses | RORγt Inverse agonist 8 is a potent, selective, orally bioavailable RORγt inverse agonist, with an IC50 of 19 nM for human RORγt-LBD[1]. | | in vivo | RORγt Inverse agonist 8 (15 mg/kg, 45 mg/kg ; i.g.; twice daily; for 7 days) ameliorates antigen-induced arthritis (AiA) responses in Lewis rats[1].
| Animal Model: | Female Lewis rats (190–220 g)[1] | | Dosage: | 15 mg/kg, 45 mg/kg | | Administration: | Oral gavage; twice daily; for 7 days | | Result: | Ameliorates antigen-induced arthritis (AiA) responses in Lewis rats. |
| | References | [1] Guendisch U, et al. Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivo. PLoS One. 2017 Nov 20;12(11):e0188391. DOI:10.1371/journal.pone.0188391 |
| | RORγt inhibitor 1 Preparation Products And Raw materials |
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