| Company Name: |
BOC Sciences |
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16314854226; +8616314854226 |
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inquiry@bocsci.com |
| Company Name: |
BOC Sciences |
| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
CFM 4 manufacturers
- CFM 4
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- $34.00
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2026-08-08
- CAS:331458-02-7
- Purity: 98.82%
- Supply Ability: 10g
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| Product Name: | CFM 4 | | Synonyms: | CFM 4;1-[(2-Chlorophenyl)methyl]-5'-phenyl-spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one;Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 1-[(2-chlorophenyl)methyl]-5'-phenyl-;CFM-4, CARP-1 mimetic | | CAS: | 331458-02-7 | | MF: | C22H16ClN3OS | | MW: | 405.9 | | EINECS: | | | Product Categories: | | | Mol File: | 331458-02-7.mol |  |
| | CFM 4 Chemical Properties |
| Boiling point | 653.4±65.0 °C(Predicted) | | density | 1.39±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in DMSO (greater than 25 mg/ml) | | form | solid | | pka | 0.13±0.20(Predicted) | | color | Tan | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| | CFM 4 Usage And Synthesis |
| Description | CFM-4 (331458-02-7) is a CARP-1 functional mimetic that interferes with CARP-1 binding to APC-2 (IC50=10-15 μM).1 Enhances CARP-1 expression and induces G2/M cell cycle arrest. Induces apoptosis and suppresses growth of medulloblastoma cells2 and malignant pleural mesothelioma cells3. | | Uses | CFM-4 is a potent small molecular antagonist of CARP-1/APC-2 binding. CFM-4 prevents CARP-1 binding with APC-2, causes G2M cell cycle arrest, and induces apoptosis with an IC50 range of 10-15 μM. CFM-4 also suppresses growth of drug-resistant human breast cancer cells[1]. | | References | [1] VINESHKUMAR THIDIL PULIYAPPADAMBA. Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis.[J]. The Journal of Biological Chemistry, 2011: 38000-38017. DOI:10.1074/jbc.m111.222398
[2] ABDELKADER E ASHOUR. CARP-1 functional mimetics: a novel class of small molecule inhibitors of medulloblastoma cell growth.[J]. PLoS ONE, 2013: e66733. DOI:10.1371/journal.pone.0066733
[3] SHAZIA JAMAL. CARP-1 functional mimetics are a novel class of small molecule inhibitors of malignant pleural mesothelioma cells.[J]. PLoS ONE, 2014: e89146. DOI:10.1371/journal.pone.0089146 |
| | CFM 4 Preparation Products And Raw materials |
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