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BOC Sciences |
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16314854226 |
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ZXH-3-26 manufacturers
- ZXH 3-26
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2026-09-17
- CAS:2243076-67-5
- Min. Order: 1mg
- Purity: 98%min
- Supply Ability: 50mg
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| | ZXH-3-26 Basic information |
| Product Name: | ZXH-3-26 | | Synonyms: | ZXH-3-26;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2-[[[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]pentyl]amino]carbonyl]-3,9-dimethyl-, methyl ester, (6S)-;methyl 2-[(9S)-7-(4-chlorophenyl)-4-[(5-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}pentyl)carbamoyl]-5,13-dimethyl-3-thia-1,8,11,12-tetraazatricyclo[8.3.0.02,?]trideca-2(6),4,7,10,12-pentaen-9-yl]acetate;Methyl (6S)-4-(4-chlorophenyl)-2-[[[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]pentyl]amino]carbonyl]-3,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetate | | CAS: | 2243076-67-5 | | MF: | C38H37ClN8O7S | | MW: | 785.27 | | EINECS: | | | Product Categories: | | | Mol File: | 2243076-67-5.mol |  |
| | ZXH-3-26 Chemical Properties |
| density | 1.55±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C, stored under nitrogen | | solubility | DMSO : 200 mg/mL (254.69 mM; Need ultrasonic) | | form | Solid | | pka | 10.75±0.40(Predicted) | | color | Light yellow to yellow |
| | ZXH-3-26 Usage And Synthesis |
| Uses | ZXH-3-26 is a PROTAC connected by ligands for Cereblon and BRD4 with a DC50/5h of 5 nM. The DC50/5h refers to half-maximal degradation after 5 hours of treatment of ~ 5 nM[1]. | | IC 50 | BRD4: 5 nM (DC50, 5 hours of treatment); Cereblon | | storage | Store at -20°C | | References | [1] Nowak RP, et al. Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat Chem Biol. 2018 Jul;14(7):706-714. DOI:10.1038/s41589-018-0055-y |
| | ZXH-3-26 Preparation Products And Raw materials |
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