|
|
| Product Name: | dBET23 | | Synonyms: | dBET23;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2-[[[8-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]octyl]amino]carbonyl]-3,9-dimethyl-, methyl ester, (6S)-;Methyl (6S)-4-(4-chlorophenyl)-2-[[[8-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]octyl]amino]carbonyl]-3,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetate | | CAS: | 1957234-83-1 | | MF: | C43H45ClN8O9S | | MW: | 885.38 | | EINECS: | | | Product Categories: | | | Mol File: | 1957234-83-1.mol |  |
| | dBET23 Chemical Properties |
| density | 1.50±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C, sealed storage, away from moisture and light | | solubility | DMSO : 170 mg/mL (192.01 mM; Need ultrasonic) | | pka | 10.68±0.40(Predicted) | | form | Solid | | color | Off-white to brown |
| | dBET23 Usage And Synthesis |
| Uses | dBET23 is a highly effective and selective PROTAC BRD4 degrader with a DC50/5h of ~ 50 nM for BRD4BD1 protein[1]. | | References | [1] Nowak RP, et al. Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat Chem Biol. 2018;14(7):706-714. DOI:10.1038/s41589-018-0055-y |
| | dBET23 Preparation Products And Raw materials |
|