| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
NFAT Transcription Factor Regulator manufacturers
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| | NFAT Transcription Factor Regulator Basic information |
| Product Name: | NFAT Transcription Factor Regulator | | Synonyms: | NFAT Transcription Factor Regulator;NFAT Transcription Factor Regulator-1;4-Pyridinecarboxamide, N-[4-[5-(difluoromethoxy)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-;NFAT Transcription Factor Regulator 1,NFAT Transcription Factor Regulator1;N-(4-(5-(Difluoromethoxy)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-3-fluoroisonicotinamide;NFAT Transcription Factor Regulator-1, 10 mM in DMSO | | CAS: | 245747-71-1 | | MF: | C17H10F6N4O2 | | MW: | 416.28 | | EINECS: | | | Product Categories: | | | Mol File: | 245747-71-1.mol |  |
| | NFAT Transcription Factor Regulator Chemical Properties |
| Boiling point | 408.4±45.0 °C(Predicted) | | density | 1.53±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : ≥ 150 mg/mL (360.33 mM);Water : < 0.1 mg/mL (insoluble) | | form | Solid | | pka | 9.85±0.70(Predicted) | | color | Light yellow to yellow |
| | NFAT Transcription Factor Regulator Usage And Synthesis |
| Uses | NFAT Transcription Factor Regulator-1 is an IL-2 synthesis inhibitor with an IC50 of 182 nM. | | Biological Activity | NFAT Transcription Factor Regulator-1 is an inhibitor of IL-2 synthesis with IC50 of 182 nM. | | in vitro | NFAT Transcription Factor Regulator-1 (compound example 19) inhibits IL-2 synthesis with an IC 50 of 182 nM. NFAT Transcription Factor Regulator-1 inhibits human and rat PBMC proliferation with IC 50 s of 82 and 146 nM, respectively. NFAT Transcription Factor Regulator-1 is able to inhibit IL-4 and IL-5 production in human T-cell lines with similar potency to its effects on IL -2 release. | | in vivo | NFAT Transcription Factor Regulator-1 is found to have an inhibitory potency approximately 10-fold better than that of cyclosporine. Comparable inhibitory effects on T-cell IL-2 production are obtained with NFAT Transcription Factor Regulator-1 and cyclosporine at doses of 3.0 and 30 mg/kg, po, respectively. The efficacies achieved in monkeys in vivo for blocking T-cell cytokine production suggest that NFAT Transcription Factor Regulator-1 has potential similar to that of cyclosporine for use in transplantation[1]. | | target | | IL-2 < span> 182 nM (IC 50 ) | | | IC 50 | IL-4; IL-5; IL-2: 182 nM (IC50) | | References | [1] Djuric SW, et al. 3,5-Bis(trifluoromethyl)pyrazoles: a novel class of NFAT transcription factor regulator. J Med Chem. 2000 Aug 10;43(16):2975-81. DOI:10.1021/jm990615a |
| | NFAT Transcription Factor Regulator Preparation Products And Raw materials |
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