R-Pralatrexate

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R-Pralatrexate Basic information
Product Name:R-Pralatrexate
Synonyms:R-Pralatrexate;Pralatrexate, (R)-;L-Glutamic acid, N-[4-[(1R)-1-[(2,4-diamino-6-pteridinyl)methyl]-3-butyn-1-yl]benzoyl]-
CAS:1320211-70-8
MF:C23H23N7O5
MW:477.47
EINECS:
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Mol File:1320211-70-8.mol
R-Pralatrexate Structure
R-Pralatrexate Chemical Properties
density 1.471±0.06 g/cm3(Predicted)
pka3.53±0.10(Predicted)
Safety Information
MSDS Information
R-Pralatrexate Usage And Synthesis
Uses(R)-Pralatrexate is the (R)-enantiomer of Pralatrexate (HY-10446). Pralatrexate is an antifolate and is a potent dihydrofolate reductasean (DHFR) inhibitor[1].
References[1] Enrica Marchi, et al. Pralatrexate Is Synergistic With the Proteasome Inhibitor Bortezomib in in Vitro and in Vivo Models of T-cell Lymphoid Malignancies. Clin Cancer Res. 2010 Jul 15;16(14):3648-58. DOI:10.1158/1078-0432.CCR-10-0671
R-Pralatrexate Preparation Products And Raw materials
Tag:R-Pralatrexate(1320211-70-8) Related Product Information
Calcium levofolinate 4-[N-(2,4-Diamino-6-pteridinylmethyl)-N-methylamino] benzoic acid Methotrexate Trimethoprim Trimetrexate 10-Propargyl-10-deazaaminopterin