5,?8,?11,?14-?Tetraoxa-?2-?azaheptadecanedioic acid, 1-?[(1α,?8α,?9β)?-?bicyclo[6.1.0]?non-?4-?yn-?9-?ylmethyl] ester manufacturers
- BCN-PEG4-acid
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2026-06-04
- CAS:1881221-47-1
- Purity:
- Supply Ability: 10g
- endo BCN-PEG4-acid
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2025-06-07
- CAS:1881221-47-1
- Min. Order: 50mg
- Purity: >95.00%
- Supply Ability: 250mg
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| | 5,?8,?11,?14-?Tetraoxa-?2-?azaheptadecanedioic acid, 1-?[(1α,?8α,?9β)?-?bicyclo[6.1.0]?non-?4-?yn-?9-?ylmethyl] ester Basic information |
| Product Name: | 5,?8,?11,?14-?Tetraoxa-?2-?azaheptadecanedioic acid, 1-?[(1α,?8α,?9β)?-?bicyclo[6.1.0]?non-?4-?yn-?9-?ylmethyl] ester | | Synonyms: | BCN-endo-PEG4-COOH;BCN-PEG4-ACID (ENDO);rel-1-((1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azanonadecan-19-oic acid;5,?8,?11,?14-?Tetraoxa-?2-?azaheptadecanedioic acid, 1-?[(1α,?8α,?9β)?-?bicyclo[6.1.0]?non-?4-?yn-?9-?ylmethyl] ester;1-((1R,8S)-bicyclo[6.1.0]non-4-yn-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azanonadecan-19-oic acid;1-[(1α,8α,9β)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl] 5,8,11,14-tetraoxa-2-azaheptade;BCN-PEG4-acid | | CAS: | 1881221-47-1 | | MF: | C22H35NO8 | | MW: | 441.52 | | EINECS: | | | Product Categories: | SiChem;PEG | | Mol File: | 1881221-47-1.mol | ![5,?8,?11,?14-?Tetraoxa-?2-?azaheptadecanedioic acid, 1-?[(1α,?8α,?9β)?-?bicyclo[6.1.0]?non-?4-?yn-?9-?ylmethyl] ester Structure](CAS/20211123/GIF/1881221-47-1.gif) |
| | 5,?8,?11,?14-?Tetraoxa-?2-?azaheptadecanedioic acid, 1-?[(1α,?8α,?9β)?-?bicyclo[6.1.0]?non-?4-?yn-?9-?ylmethyl] ester Chemical Properties |
| Boiling point | 608.2±55.0 °C(Predicted) | | density | 1.20±0.1 g/cm3(Predicted) | | storage temp. | Storage temp. 2-8°C | | form | Viscous Liquid | | pka | 4.28±0.10(Predicted) | | color | Colorless to light yellow |
| | 5,?8,?11,?14-?Tetraoxa-?2-?azaheptadecanedioic acid, 1-?[(1α,?8α,?9β)?-?bicyclo[6.1.0]?non-?4-?yn-?9-?ylmethyl] ester Usage And Synthesis |
| Uses | endo-BCN-PEG4-acid is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. endo-BCN-PEG4-acid is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | | IC 50 | Cleavable Linker | | References | [1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
| | 5,?8,?11,?14-?Tetraoxa-?2-?azaheptadecanedioic acid, 1-?[(1α,?8α,?9β)?-?bicyclo[6.1.0]?non-?4-?yn-?9-?ylmethyl] ester Preparation Products And Raw materials |
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