endo-BCN-PEG2-acid manufacturers
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| | endo-BCN-PEG2-acid Basic information |
| Product Name: | endo-BCN-PEG2-acid | | Synonyms: | endo-BCN-PEG2-acid;4,7,12-Trioxa-10-azatridecanoic acid, 13-(1R,8S)-bicyclo[6.1.0]non-4-yn-9-yl-11-oxo-, rel-;endo-BCN-PEG2-acid endo-bcn-;1-[(1R,8S,9S)-rel-Bicyclo[6.1.0]non-4-yn-9-yl]-3-oxo-2,7,10-trioxa-4-azatridecan-13-oic Acid | | CAS: | 1993134-72-7 | | MF: | C18H27NO6 | | MW: | 353.41 | | EINECS: | | | Product Categories: | | | Mol File: | 1993134-72-7.mol |  |
| | endo-BCN-PEG2-acid Chemical Properties |
| Boiling point | 546.4±40.0 °C(Predicted) | | density | 1.21±0.1 g/cm3(Predicted) | | storage temp. | -20°C, sealed storage, away from moisture | | solubility | Soluble in DMSO, DCM, DMF | | form | Liquid | | pka | 4.28±0.10(Predicted) | | color | Colorless to light yellow |
| | endo-BCN-PEG2-acid Usage And Synthesis |
| Description | endo-BCN-PEG2-acid is a PEG linker containing a BCN group and a terminal carboxylic acid. The BCN group can react with azide-tagged biomolecules. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | | Uses | endo-BCN-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. endo-BCN-PEG2-acid is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | | IC 50 | PEGs | | References | [1] Sano K, et al. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. Bioconjug Chem. 2013 May 15;24(5):811-6. DOI:10.1021/bc400050k |
| | endo-BCN-PEG2-acid Preparation Products And Raw materials |
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