H-GLY-PRO-GLY-NH2 HCL

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Company Name: Nanjing Leon Biological Technology Co., Ltd.  
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H-GLY-PRO-GLY-NH2 HCL Basic information
Product Name:H-GLY-PRO-GLY-NH2 HCL
Synonyms:H-GLY-PRO-GLY-NH2 HCL;H-Gly-Pro-Gly-NH2;H-Gly-Pro-Gly-NH2 hydrochloride;GPG-NH2;Glycinamide, glycyl-L-prolyl-;Glycyl-L-prolylglycinamide
CAS:141497-12-3
MF:C9H16N4O3
MW:228.25
EINECS:
Product Categories:
Mol File:141497-12-3.mol
H-GLY-PRO-GLY-NH2 HCL Structure
H-GLY-PRO-GLY-NH2 HCL Chemical Properties
Boiling point 618.0±55.0 °C(Predicted)
density 1.326±0.06 g/cm3(Predicted)
storage temp. -15°C
pka14.27±0.20(Predicted)
SequenceH-Gly-Pro-Gly-NH2 · HCl
Safety Information
MSDS Information
H-GLY-PRO-GLY-NH2 HCL Usage And Synthesis
UsesH-Gly-Pro-Gly-NH2 is a tripeptide that inhibits HIV-1 replication. H-Gly-Pro-Gly-NH2 inhibits the activity of HIV-1 IIIB and HIV-2 ROD with EC50 values of 35 μM and 30 μM, respectively. H-Gly Pro Gly NH2 inhibits HIV-1 replication in vitro by interfering with capsid formation. H-Gly Pro Gly NH2 has antiviral activity and can be used for virus research[1][2][3].
IC 50HIV (IIIB): 35 μM (EC50); HIV-2 (ROD): 30 μM (EC50)
References[1] Hglund S, et al. Tripeptide interference with human immunodeficiency virus type 1 morphogenesis. Antimicrob Agents Chemother. 2002 Nov;46(11):3597-605. DOI:10.1128/AAC.46.11.3597-3605.2002
[2] Andersson E, et al. No cross-resistance or selection of HIV-1 resistant mutants in vitro to the antiretroviral tripeptide glycyl-prolyl-glycine-amide[J]. Antiviral research, 2004, 61(2): 119-124.
[3] Balzarini J, et al. Obligatory involvement of CD26/dipeptidyl peptidase IV in the activation of the antiretroviral tripeptide glycylprolylglycinamide (GPG-NH(2)). Int J Biochem Cell Biol. 2004 Sep;36(9):1848-59. DOI:10.1016/j.biocel.2004.02.017
H-GLY-PRO-GLY-NH2 HCL Preparation Products And Raw materials
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