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| | (S)-PBMC
(PBMC) Basic information |
| Product Name: | (S)-PBMC
(PBMC) | | Synonyms: | (S)-PBMC
(PBMC);Carbamic acid, N-(2-aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-, (1S)-1-phenylethyl ester;N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-carbamic acid (1S)-1-phenylethyl ester | | CAS: | 1352138-54-5 | | MF: | C26H30N2O4 | | MW: | 434.53 | | EINECS: | | | Product Categories: | | | Mol File: | 1352138-54-5.mol |  |
| | (S)-PBMC
(PBMC) Chemical Properties |
| Boiling point | 584.6±50.0 °C(Predicted) | | density | 1.165±0.06 g/cm3(Predicted) | | storage temp. | -20°C (des.) | | solubility | Soluble in DMSO (up to 30 mg/ml). | | pka | 9.17±0.10(Predicted) | | form | oil | | color | Light brown | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| | (S)-PBMC
(PBMC) Usage And Synthesis |
| Description | PBMC (1352138-54-5) is a potent and selective blocker of TRPM8 channels. PBMC blocks both chemical and thermal activation of TRPM8.1Reverses the menthol and cold-induced facilitation of the micturition reflex.2PBMC represents a new lead for analgesic drugs based on blocking TRPM8.3 | | References | [1] WENDY M KNOWLTON. Pharmacological blockade of TRPM8 ion channels alters cold and cold pain responses in mice.[J]. PLoS ONE, 2011: e25894. DOI:10.1371/journal.pone.0025894
[2] JENNIFER C. GARDINER . The role of TRPM8 in the Guinea-pig bladder-cooling reflex investigated using a novel TRPM8 antagonist[J]. European journal of pharmacology, 2014, 740: Pages 398-409. DOI:10.1016/j.ejphar.2014.07.022
[3] KINGA SAŁAT Tadeusz L Andrzej Moniczewski. Transient receptor potential channels - emerging novel drug targets for the treatment of pain.[J]. Current medicinal chemistry, 2013, 20 11: 1409-1436. DOI:10.2174/09298673113209990107 |
| | (S)-PBMC
(PBMC) Preparation Products And Raw materials |
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