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Sigma-Aldrich |
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021-61415566 800-8193336 |
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4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime manufacturers
- AP 18
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- $40.00
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2026-07-20
- CAS:55224-94-7
- Purity: 99.85%
- Supply Ability: 10g
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| | 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime Basic information |
| Product Name: | 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime | | Synonyms: | AP-18;4-(4-Chlorophenyl)-3-methyl-3-buten-2-oneoxime;4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime;4-(4-Chlorophenyl)-3-methylbut-3-en-2-one oxime;3-Buten-2-one, 4-(4-chlorophenyl)-3-methyl-, oxime;ganglia,TRP Channel,nerves,pain,AP18,Transient receptor potential channels,AP-18,AP 18,inhibit,nociceptive,root,hyperalgesia,Inhibitor,transduction,dorsal;AP-18, TRPA1 receptor antagonist;AP 18, 10 mM in DMSO | | CAS: | 55224-94-7 | | MF: | C11H12ClNO | | MW: | 209.67 | | EINECS: | | | Product Categories: | Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals | | Mol File: | 55224-94-7.mol |  |
| | 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime Chemical Properties |
| Boiling point | 348.381±34.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.099±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | 2-8°C | | solubility | DMSO: >10mg/mL | | form | solid | | pka | 11.734±0.10(predicted) | | color | white to off-white | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. | | InChI | 1S/C11H12ClNO/c1-8(9(2)13-14)7-10-3-5-11(12)6-4-10/h3-7,14H,1-2H3/b8-7+,13-9+ | | InChIKey | MHTJEUOFLVQMCL-NJHPPEEMSA-N | | SMILES | CC(=C/c1ccc(Cl)cc1)\C(C)=N\O |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral |
| | 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime Usage And Synthesis |
| Description | AP-18 is a channel blocker which reversibly inhibits TRPA1 (IC50s = 3.1 and 4.5 μM, human and mouse, respectively). It has minimal effect on TRPV1-4 or TRPM8. AP-18 has been used to study TRPA1 signaling in mice and rats as well as in vitro. | | Uses | AP-18 is a selective TRPA1 channel blocker. AP-18 blocks the transient receptor potential ankyrin 1 receptors and can reduce chronic pain associated with arthritis. AP-18 reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation. AP-18 reverses CFA-induced mechanical hyperalgesia in mice | | Uses | AP-18 is a channel blocker that inhibits TRPA1. | | Biological Activity | Reversible TRPA1 channel blocker (IC 50 values are 3.1 and 4.5 μ M at human and mouse TRPA1 respectively). Blocks cinnameldehyde-induced but not capsaicin-induced nociception and reverses mechanical hyperalgesia in vivo . Also blocks TRPA1 pore dilation (IC 50 = 10.3 μM for the inhibition of Yo-Pro uptake). | | Biochem/physiol Actions | AP-18 is a selective TRPA1 channel blocker. Transient receptor potential A1 (TRPA1) plays a central role for chemical sensing in the pain pathway. AP-18 is a novel TRPA1 channel blocker. It reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation demonstrating selectivity vs. TRPV11. AP-18 reverses CFA-induced mechanical hyperalgesia in mice. | | in vivo | ap-18 blocks the transient receptor potential ankyrin 1 receptors and can reduce chronic pain associated with arthritis. this product is also capable to induce cinnamaldehyde-induced nociception and to block cold- and mustard oil-induced activation of mouse trpa1 but not capsaicin-induced activation 2. in addition, ap18 treatment reversed cfa-induced mechanical hyperalgesia in mice 2. thus, trpa1 is essential for sensitization of nociception. | | storage | +4°C | | References | [1] SIEMENS H, ROODT V. References and Citations[C]. 2008: 0. DOI:10.1515/9783110217339.0.xiii |
| | 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime Preparation Products And Raw materials |
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