Borussertib manufacturers
- Borussertib
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- $98.00
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2026-08-20
- CAS:1800070-77-2
- Purity: 99.19%
- Supply Ability: 10g
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| | Borussertib Basic information |
| Product Name: | Borussertib | | Synonyms: | Borussertib;2-Propenamide, N-[3-[1-[[4-(5,6-dihydro-5-oxo-3-phenyl-1,6-naphthyridin-2-yl)phenyl]methyl]-4-piperidinyl]-2,3-dihydro-2-oxo-1H-benzimidazol-5-yl]-;Borussertib,Inhibitor,PKB,Akt,Protein kinase B,inhibit;Borussertib, 10 mM in DMSO;N-[2-oxo-3-(1-{[4-(5-oxo-3-phenyl-6H-1,6-naphthyridin-2-yl)phenyl]methyl}piperidin-4-yl)-1H-1,3-benzodiazol-5-yl]prop-2-enamide - [AC80954] | | CAS: | 1800070-77-2 | | MF: | C36H32N6O3 | | MW: | 596.68 | | EINECS: | | | Product Categories: | | | Mol File: | 1800070-77-2.mol |  |
| | Borussertib Chemical Properties |
| density | 1.318±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 25 mg/mL (41.90 mM; Need ultrasonic) | | pka | 10.74±0.20(Predicted) | | form | Solid | | color | White to off-white |
| | Borussertib Usage And Synthesis |
| Uses | Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt, with an IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt[1]. | | References | [1] Niklas Uhlenbrock, et al. Structural and chemical insights into the covalentallosteric inhibition of the protein kinase Akt. Chem Sci., 2019, 10, 3573. |
| | Borussertib Preparation Products And Raw materials |
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