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NCE Biomedical Co.,Ltd. |
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4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 |
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| | Triciribine Basic information |
| Product Name: | Triciribine | | Synonyms: | 1-(5-O-Phosphono-β-D-ribofuranosyl)-5-methyl-1,5-dihydro-1,4,5,6,8-pentaazaacenaphthylene-3-amine;1,5-Dihydro-5-methyl-1-(5-O-phosphono-β-D-ribofuranosyl)-1,4,5,6,8-pentaazaacenaphthylene-3-amine;NSC-280594;TCN-P;1,4,5,6,8-Pentaazaacenaphthylene-3-amino-1,5-dihydro-5-methyl-1-beta-D-ribofuranosyl 5'-monophosphate;VQD 002;(1R,2S,3R,5R)-3-(3-aMino-5-Methyl-1,4,5,6,8-pentaazaacenaphthylen-1(5H)-yl)-5-(hydroxyMethyl)cyclopentane-1,2-diol;VQD-002 (TCN-P) | | CAS: | 61966-08-3 | | MF: | C13H17N6O7P | | MW: | 400.286 | | EINECS: | | | Product Categories: | | | Mol File: | 61966-08-3.mol |  |
| | Triciribine Chemical Properties |
| density | 2.23 | | solubility | PBS (pH 7.2): 10 mg/ml | | form | Solid | | color | Light yellow to yellow |
| | Triciribine Usage And Synthesis |
| Uses | Triciribine phosphate is an Akt activation inhibitor that inhibits Akt phosphorylation by binding to the pleckstrin homology (PH) domain of the Akt and blocking its recruitment to the plasma membrane. | | Brand name | Triciribine is INN. | | References | [1] N BERNDT. The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane[J]. Cell Death and Differentiation, 2010, 17 11: 1795-1804. DOI: 10.1038/cdd.2010.63
[2] PLAGEMANN P G. Transport, phosphorylation, and toxicity of a tricyclic nucleoside in cultured Novikoff rat hepatoma cells and other cell lines and relase of its monophosphate by the cells.[J]. JNCI Journal of the National Cancer Institute, 1976, 57 6: 1283-1295. DOI: 10.1093/jnci/57.6.1283
[3] B C BEHRENS. Activity of tricyclic nucleoside 5’-phosphate in model systems of human ovarian cancer.[J]. Investigational New Drugs, 1986, 4 4: 295-304. DOI: 10.1007/bf00173502
[4] ANTHONY R. PORCARI. Deoxy Sugar Analogues of Triciribine: Correlation of Antiviral and Antiproliferative Activity with Intracellular Phosphorylation[J]. Journal of Medicinal Chemistry, 2000, 43 12: 2438-2448. DOI: 10.1021/jm990205m |
| | Triciribine Preparation Products And Raw materials |
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