D5D-IN-326
| 中文名称 | D5D-IN-326 |
|---|---|
| 中文同义词 | 化合物 T15043;化合物 D5D-IN-326 |
| 英文名称 | D5D-IN-326 |
| 英文同义词 | D5D-IN-326;3H-Pyrrolo[2,3-d]pyrimidine-4,6-dione, 5,7-dihydro-2-(2,2,3,3,3-pentafluoropropoxy)-3-[4-(2,2,2-trifluoroethoxy)phenyl]-;D-5D-IN-326,D5D IN 326,D5DIN326 |
| CAS号 | 1236767-85-3 |
| 分子式 | C17H11F8N3O4 |
| 分子量 | 473.27 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1236767-85-3.mol |
| 结构式 |  |
D5D-IN-326 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 固体 |
| 颜色 | 浅紫色至紫色 |
| InChI | 1S/C17H11F8N3O4/c18-15(19,17(23,24)25)6-32-14-27-12-10(5-11(29)26-12)13(30)28(14)8-1-3-9(4-2-8)31-7-16(20,21)22/h1-5,26,29H,6-7H2 |
| InChIKey | VKDOANVHEBFXOC-UHFFFAOYSA-N |
| SMILES | FC(F)(F)C(F)(F)COc1[n]([c](c3c([nH]c(c3)O)n1)=O)c2ccc(cc2)OCC(F)(F)F |
IC50: 72 nM (Rat D5D), 22 nM (Human D5D)
D5D-IN-326 is a selective, orally active delta-5 desaturase (D5D) inhibitor, with IC 50 s of 72 and 22 nM for rat and human D5D in enzymic and cell-based assays, respectively, has no effect on D6D or D9D activity.
D5D-IN-326 (0.1, 1, and 10 mg/kg, p.o. for 6 weeks) gradually decreases body weight at 10 mg/kg, but lowers doses are not effective in DIO mice after treatment for 6 weeks.
D5D-IN-326 (10 mg/kg, p.o. for 6 weeks) also significantly decreases gene expression levels of
Ccl2
,
Cd68
,
Adgre1
, and
Il6
, decreases epididymal
Lep
and
Adipoq
mRNAs which are significantly increased in HFD DIO mice.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-117427 | D5D-IN-326 D5D-IN-326 | 1236767-85-3 | 5 mg | 975元 |
| 2026/06/05 | HY-117427 | D5D-IN-326 D5D-IN-326 | 1236767-85-3 | 10mM * 1mLin DMSO | 1015元 |