Elenbecestat manufacturers
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| | Elenbecestat Basic information |
| Product Name: | Elenbecestat | | Synonyms: | 2-Pyrazinecarboxamide, N-[3-[(4aS,5S,7aS)-2-amino-4a,5-dihydro-5-(trifluoromethyl)-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl]-4-fluorophenyl]-5-(difluoromethyl)-;Elenbecestat free base | | CAS: | 1388149-39-0 | | MF: | C19H15F6N5O2S | | MW: | 491.41 | | EINECS: | | | Product Categories: | | | Mol File: | 1388149-39-0.mol |  |
| | Elenbecestat Chemical Properties |
| solubility | Soluble in DMSO:80.0(Max Conc. mg/mL);182.88(Max Conc. mM) |
| | Elenbecestat Usage And Synthesis |
| Description | Elenbecestat,also known as E2609 is a BACE1 inhibitor. By inhibiting BACE, a key enzyme in the production of Aβ peptides, E2609 decreases the formation of these peptides which can aggregate into toxic oligomers and protofibrils and eventually form amyloid plaques in the brain. Elenbecestat has been shown to reduce Aβ levels in cerebrospinal fluid, was investigated in two global phase 3 studies in early AD. | | Uses | BACE-IN-3 (Example 3) is a BACE inhibitor, with an IC50 of 0.004 μM[1]. | | References | [1] Adrian Hall, et al. Dérivés d'aminodihydrothiazine condensés utiles en tant qu'inhibiteurs de bace. Patent WO2012098213A1. |
| | Elenbecestat Preparation Products And Raw materials |
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