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| | Oxycodegol Basic information |
| Product Name: | Oxycodegol | | Synonyms: | Oxycodegol;NKTR-181;Loxicodegol;Morphinan-14-ol, 4,5-epoxy-6-(3,6,9,12,15,18-hexaoxanonadec-1-yloxy)-3-methoxy-17-methyl-, (5α,6α)- | | CAS: | 1211231-76-3 | | MF: | C31H49NO10 | | MW: | 595.73 | | EINECS: | | | Product Categories: | | | Mol File: | 1211231-76-3.mol |  |
| | Oxycodegol Chemical Properties |
| Boiling point | 679.2±55.0 °C(Predicted) | | density | 1.23±0.1 g/cm3(Predicted) | | pka | 13.40±0.40(Predicted) |
| | Oxycodegol Usage And Synthesis |
| Uses | Loxicodegol (Oxycodegol) is a first-in-class, long-acting, orally active, and selective mu-opioid agonist with structural properties that reduce its rate of entry across the blood-brain barrier compared with traditional mu-opioid agonists[1][2]. | | References | [1] Miyazaki T, et al. NKTR-181: A Novel Mu-Opioid Analgesic with Inherently Low Abuse Potential. J Pharmacol Exp Ther. 2017;363(1):104-113. DOI:10.1124/jpet.117.243030
[2] Gudin J, et al. Long-term Safety and Tolerability of NKTR-181 in Patients with Moderate to Severe Chronic Low Back Pain or Chronic Noncancer Pain: A Phase 3 Multicenter, Open-Label, 52-Week Study (SUMMIT-08 LTS). Pain Med. 2020;21(7):1347-1356. DOI:10.1093/pm/pnz169 |
| | Oxycodegol Preparation Products And Raw materials |
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